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Białek A, Białek M, Lepionka T, et al. Cancer Influences the Elemental Composition of the Myocardium More Strongly than Conjugated Linoleic Acids-Chemometric Approach to Cardio-Oncological Studies. Molecules. 2021;26(23)doi: 10.3390/molecules26237127.
Białek, A., Białek, M., Lepionka, T., Ruszczyńska, A., Bulska, E., & Czauderna, M. (2021). Cancer Influences the Elemental Composition of the Myocardium More Strongly than Conjugated Linoleic Acids-Chemometric Approach to Cardio-Oncological Studies. Molecules (Basel, Switzerland), 26(23), . https://doi.org/10.3390/molecules26237127
Białek, Agnieszka, et al. "Cancer Influences the Elemental Composition of the Myocardium More Strongly than Conjugated Linoleic Acids-Chemometric Approach to Cardio-Oncological Studies." Molecules (Basel, Switzerland) vol. 26,23 (2021). doi: https://doi.org/10.3390/molecules26237127
Białek A, Białek M, Lepionka T, Ruszczyńska A, Bulska E, Czauderna M. Cancer Influences the Elemental Composition of the Myocardium More Strongly than Conjugated Linoleic Acids-Chemometric Approach to Cardio-Oncological Studies. Molecules. 2021 Nov 25;26(23). doi: 10.3390/molecules26237127. PMID: 34885709; PMCID: PMC8659207.
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Molecules. 2021 Nov 25;26(23). doi: 10.3390/molecules26237127.

Cancer Influences the Elemental Composition of the Myocardium More Strongly than Conjugated Linoleic Acids-Chemometric Approach to Cardio-Oncological Studies.

Molecules (Basel, Switzerland)

Agnieszka Białek, Małgorzata Białek, Tomasz Lepionka, Anna Ruszczyńska, Ewa Bulska, Marian Czauderna

Affiliations

  1. Department of Biotechnology and Nutrigenomics, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Post?pu 36A Jastrz?biec, 05-552 Magdalenka, Poland.
  2. Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jab?onna, Poland.
  3. Department of Bioaerosols, The Biological Threats Identification and Countermeasure Center of the General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Lubelska 4 St, 24-100 Pu?awy, Poland.
  4. Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, ?wirki i Wigury 101, 02-089 Warsaw, Poland.

PMID: 34885709 PMCID: PMC8659207 DOI: 10.3390/molecules26237127

Abstract

The aim of the study was to verify in a cardio-oncological model experiment if conjugated linoleic acids (CLA) fed to rats with mammary tumors affect the content of selected macro- and microelements in their myocardium. The diet of Sprague-Dawley females was supplemented either with CLA isomers or with safflower oil. In hearts of rats suffering from breast cancer, selected elements were analyzed with a quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS). In order to better understand the data trends, cluster analysis, principal component analysis and linear discriminant analysis were applied. Mammary tumors influenced macro- and microelements content in the myocardium to a greater extent than applied diet supplementation. Significant influences of diet (

Keywords: breast cancer; cardio-oncology; chemometry; conjugated linoleic acid; heart

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