Int J Clin Pharmacol Ther. 2021 Dec 10; doi: 10.5414/CP204139. Epub 2021 Dec 10.

Drug-induced, mixed-type hepatitis following ingestion of .

International journal of clinical pharmacology and therapeutics

Dario Thurian, Matteo Montani, Felix Stickel

PMID: 34889735 DOI: 10.5414/CP204139

Abstract

The use of herbal and dietary supplements is increasing worldwide. Consumers consider it as a natural, and therefore safe and healthy alternative to conventional synthetic drugs and do not expect adverse effects. However, numerous herbal and dietary supplements have been associated with adverse hepatic reactions of variable severity. Recognition of adverse hepatic reactions following the ingestion of herbal and dietary supplements is sometimes difficult since clinical presentation can resemble that of other etiologies unrelated to xenobiotics. Pharmacovigilance is based on spontaneous reporting and, thus, many incidents probably remain unrecorded due to lack of awareness among users and prescribers. The present report describes the first case of cholestatic hepatitis after the intake of an herbal supplement containing

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• Journal Article