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Sonuga-Barke EJS, Hanć T, Stehli A, et al. Severe deprivation in early childhood leads to permanent growth stunting: Longitudinal analysis of height trajectories from childhood-to-adulthood. Child Abuse Negl. 2021;123:105427doi: 10.1016/j.chiabu.2021.105427.
Sonuga-Barke, E. J. S., Hanć, T., Stehli, A., Trampush, J. W., Kennedy, M., Kreppner, J., Rutter, M., Swanson, J. M. (2021). Severe deprivation in early childhood leads to permanent growth stunting: Longitudinal analysis of height trajectories from childhood-to-adulthood. Child abuse & neglect, 123105427. https://doi.org/10.1016/j.chiabu.2021.105427
Sonuga-Barke, Edmund J S, et al. "Severe deprivation in early childhood leads to permanent growth stunting: Longitudinal analysis of height trajectories from childhood-to-adulthood." Child abuse & neglect vol. 123 (2021): 105427. doi: https://doi.org/10.1016/j.chiabu.2021.105427
Sonuga-Barke EJS, Hanć T, Stehli A, Trampush JW, Kennedy M, Kreppner J, Rutter M, Swanson JM. Severe deprivation in early childhood leads to permanent growth stunting: Longitudinal analysis of height trajectories from childhood-to-adulthood. Child Abuse Negl. 2021 Dec 09;123:105427. doi: 10.1016/j.chiabu.2021.105427. Epub 2021 Dec 09. PMID: 34896879.
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Child Abuse Negl. 2021 Dec 09;123:105427. doi: 10.1016/j.chiabu.2021.105427. Epub 2021 Dec 09.

Severe deprivation in early childhood leads to permanent growth stunting: Longitudinal analysis of height trajectories from childhood-to-adulthood.

Child abuse & neglect

Edmund J S Sonuga-Barke, Tomasz Hanć, Annamarie Stehli, Joey W Trampush, Mark Kennedy, Jana Kreppner, Michael Rutter, James M Swanson,

Affiliations

  1. Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, DeCrespigny Park, London SE5 8AF, UK; Department of Child & Adolescent Psychiatry, Aarhus University, Denmark. Electronic address: [email protected].
  2. Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, ul. Uniwersytetu Poznanskiego 6, 61-614 Poznan, Poland.
  3. Department of Pediatrics, University of California, Irvine, 333 The City Blvd. West, Suite 800, Orange, CA 92868-4482, USA.
  4. Department of Psychiatry and the Behavioural Sciences, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, Suite 2200, Los Angeles, CA 90033, USA.
  5. Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, DeCrespigny Park, London SE5 8AF, UK.
  6. Centre for Innovation in Mental Health, School of Psychology, University of Southampton, University Road, Southampton SO17 1BJ, UK.
  7. Social, Developmental, Genetic Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, DeCrespigny Park, London, SE5 8AF, UK.

PMID: 34896879 DOI: 10.1016/j.chiabu.2021.105427

Abstract

BACKGROUND: Childhood institutional deprivation is associated with growth stunting in childhood but long-term effects in adulthood remain uncertain.

OBJECTIVE: To examine the impact of global institutional deprivation experienced in early childhood on subsequent growth with a special focus on final adult height and puberty timing.

PARTICIPANTS & SETTING: The study was originally set in the UK, though some adoptive families lived abroad by the time of the adult follow up. 165 individuals adopted by UK families before 43 months of age from Romanian orphanages after the fall of the Ceaușescu regime in the early 1990's were compared to 51 non-deprived UK adoptees, adopted before the age of 6 months.

METHODS: The English and Romanian Adoptees (ERA) study is a 20-year longitudinal natural experiment on the effects of institutional deprivation on development. Key growth milestones were extracted from growth curve modelling of height data collected at ages 4, 6, 11, 15 and 23 years using a Bayesian approach to fit the JPA2 model.

RESULTS: Deprivation effects on height were present at the take-off point of accelerating adolescent growth and persisted into adulthood - the largest effects being for individuals who experienced over six months of deprivation. Deprivation was associated with earlier take-off and achievement of peak height velocity of adolescent growth acceleration - an effect driven largely by females' data and correlated with parent ratings of pubertal development.

CONCLUSIONS: Early deprivation appears to reset tempo of growth early in development leading to permanent growth stunting in adulthood and accelerated onset of puberty, specifically in females.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Adoption; Growth; Height; Institutional deprivation; Puberty; Subnutrition

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