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Fan L, Namani R, Choy JS, et al. Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility. Front Physiol. 2021;12:744855doi: 10.3389/fphys.2021.744855.
Fan, L., Namani, R., Choy, J. S., Kassab, G. S., & Lee, L. C. (2021). Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility. Frontiers in physiology, 12744855. https://doi.org/10.3389/fphys.2021.744855
Fan, Lei, et al. "Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility." Frontiers in physiology vol. 12 (2021): 744855. doi: https://doi.org/10.3389/fphys.2021.744855
Fan L, Namani R, Choy JS, Kassab GS, Lee LC. Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility. Front Physiol. 2021 Nov 24;12:744855. doi: 10.3389/fphys.2021.744855. eCollection 2021. PMID: 34899378; PMCID: PMC8652301.
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Front Physiol. 2021 Nov 24;12:744855. doi: 10.3389/fphys.2021.744855. eCollection 2021.

Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility.

Frontiers in physiology

Lei Fan, Ravi Namani, Jenny S Choy, Ghassan S Kassab, Lik Chuan Lee

Affiliations

  1. Department of Mechanical Engineering, Michigan State University, East Lansing, MI, United States.
  2. California Medical Innovations Institute, San Diego, CA, United States.

PMID: 34899378 PMCID: PMC8652301 DOI: 10.3389/fphys.2021.744855

Abstract

Myocardial supply changes to accommodate the variation of myocardial demand across the heart wall to maintain normal cardiac function. A computational framework that couples the systemic circulation of a left ventricular (LV) finite element model and coronary perfusion in a closed loop is developed to investigate the transmural distribution of the myocardial demand (work density) and supply (perfusion) ratio. Calibrated and validated against measurements of LV mechanics and coronary perfusion, the model is applied to investigate changes in the transmural distribution of passive coronary perfusion, myocardial work density, and their ratio in response to changes in LV contractility, preload, afterload, wall thickness, and cavity volume. The model predicts the following:

Copyright © 2021 Fan, Namani, Choy, Kassab and Lee.

Keywords: cardiac mechanics; cardiac work; computational modeling; coronary flow; myocardial work density-perfusion mismatch

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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