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Front Neurol. 2021 Nov 24;12:623358. doi: 10.3389/fneur.2021.623358. eCollection 2021.

Distinct Patterns of Brain Metabolism in Patients at Risk of Sudden Unexpected Death in Epilepsy.

Frontiers in neurology

Benjamin P Whatley, Joel S Winston, Luke A Allen, Sjoerd B Vos, Ashwani Jha, Catherine A Scott, April-Louise Smith, Fahmida A Chowdhury, Jamshed B Bomanji, Samden D Lhatoo, Ronald M Harper, Beate Diehl

Affiliations

  1. Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom.
  2. Division of Neurology, Dalhousie University, Halifax, NS, Canada.
  3. Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
  4. Wellcome Trust Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, London, United Kingdom.
  5. Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
  6. Department of Clinical Neurophysiology, King's College Hospital, London, United Kingdom.
  7. Epilepsy Society MRI Unit, Chalfont St Peter, United Kingdom.
  8. The Center for SUDEP Research, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, United States.
  9. Neuroradiological Academic Unit, Queen Square Institute of Neurology, University College London, London, United Kingdom.
  10. Centre for Medical Image Computing, University College London, London, United Kingdom.
  11. Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom.
  12. Institute of Nuclear Medicine, University College London, London, United Kingdom.
  13. Epilepsy Center, Neurological Institute, University Hospitals Case Medical Center, Cleveland, OH, United States.
  14. Department of Neurology, University of Texas Health Sciences Center at Houston, Houston, TX, United States.
  15. Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.
  16. Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, United States.

PMID: 34899550 PMCID: PMC8651549 DOI: 10.3389/fneur.2021.623358

[No abstract available.]

Copyright © 2021 Whatley, Winston, Allen, Vos, Jha, Scott, Smith, Chowdhury, Bomanji, Lhatoo, Harper and Diehl.

Keywords: SUDEP; bilateral tonic-clonic seizure; cardiorespiratory regulation; central autonomic regulation; epilepsy; positron emission tomography

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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