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Wegman AD, Fang H, Rothman AL, et al. Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection. Front Immunol. 2021;12:777672doi: 10.3389/fimmu.2021.777672.
Wegman, A. D., Fang, H., Rothman, A. L., Thomas, S. J., Endy, T. P., McCracken, M. K., Currier, J. R., Friberg, H., Gromowski, G. D., & Waickman, A. T. (2021). Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection. Frontiers in immunology, 12777672. https://doi.org/10.3389/fimmu.2021.777672
Wegman, Adam D, et al. "Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection." Frontiers in immunology vol. 12 (2021): 777672. doi: https://doi.org/10.3389/fimmu.2021.777672
Wegman AD, Fang H, Rothman AL, Thomas SJ, Endy TP, McCracken MK, Currier JR, Friberg H, Gromowski GD, Waickman AT. Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection. Front Immunol. 2021 Nov 24;12:777672. doi: 10.3389/fimmu.2021.777672. eCollection 2021. PMID: 34899736; PMCID: PMC8654368.
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Front Immunol. 2021 Nov 24;12:777672. doi: 10.3389/fimmu.2021.777672. eCollection 2021.

Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection.

Frontiers in immunology

Adam D Wegman, Hengsheng Fang, Alan L Rothman, Stephen J Thomas, Timothy P Endy, Michael K McCracken, Jeffrey R Currier, Heather Friberg, Gregory D Gromowski, Adam T Waickman

Affiliations

  1. Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY, United States.
  2. Department of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island, Providence, RI, United States.
  3. Institute for Global Health and Translational Sciences, State University of New York Upstate Medical University, Syracuse, NY, United States.
  4. Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.

PMID: 34899736 PMCID: PMC8654368 DOI: 10.3389/fimmu.2021.777672

Abstract

Dengue virus (DENV) is a prevalent human pathogen, infecting approximately 400 million individuals per year and causing symptomatic disease in approximately 100 million. A distinct feature of dengue is the increased risk for severe disease in some individuals with preexisting DENV-specific immunity. One proposed mechanism for this phenomenon is antibody-dependent enhancement (ADE), in which poorly-neutralizing IgG antibodies from a prior infection opsonize DENV to increase infection of F

Copyright © 2021 Wegman, Fang, Rothman, Thomas, Endy, McCracken, Currier, Friberg, Gromowski and Waickman.

Keywords: ADE; DENV; Dengue; IgA; antibody dependent enhancement

Conflict of interest statement

Authors ADW, MM, JC, HF, GG, and ATW are co-inventors on the provisional patent “IgA monoclonal antibodies as a prophylactic and therapeutic treatment for acute flavivirus infection”. The remaining au

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