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Kilbane MT, Crowley R, Heffernan E, et al. High bone turnover and hyperparathyroidism after surgery for tumor-induced osteomalacia: A case series. Bone Rep. 2021;15:101142doi: 10.1016/j.bonr.2021.101142.
Kilbane, M. T., Crowley, R., Heffernan, E., D'Arcy, C., O'Toole, G., Twomey, P. J., & McKenna, M. J. (2021). High bone turnover and hyperparathyroidism after surgery for tumor-induced osteomalacia: A case series. Bone reports, 15101142. https://doi.org/10.1016/j.bonr.2021.101142
Kilbane, Mark T, et al. "High bone turnover and hyperparathyroidism after surgery for tumor-induced osteomalacia: A case series." Bone reports vol. 15 (2021): 101142. doi: https://doi.org/10.1016/j.bonr.2021.101142
Kilbane MT, Crowley R, Heffernan E, D'Arcy C, O'Toole G, Twomey PJ, McKenna MJ. High bone turnover and hyperparathyroidism after surgery for tumor-induced osteomalacia: A case series. Bone Rep. 2021 Oct 09;15:101142. doi: 10.1016/j.bonr.2021.101142. eCollection 2021 Dec. PMID: 34901333; PMCID: PMC8640873.
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Bone Rep. 2021 Oct 09;15:101142. doi: 10.1016/j.bonr.2021.101142. eCollection 2021 Dec.

High bone turnover and hyperparathyroidism after surgery for tumor-induced osteomalacia: A case series.

Bone reports

Mark T Kilbane, Rachel Crowley, Eric Heffernan, Clare D'Arcy, Gary O'Toole, Patrick J Twomey, Malachi J McKenna

Affiliations

  1. Department of Clinical Chemistry, St. Vincent's University Hospital, Dublin, Ireland.
  2. Department of Endocrinology, St. Vincent's University Hospital, Dublin, Ireland.
  3. UCD School of Medicine, University College Dublin, Dublin, Ireland.
  4. Department of Diagnostic Imaging, St. Vincent's University Hospital, Dublin, Ireland.
  5. Department of Histopathology, St. Vincent's University Hospital, Dublin, Ireland.
  6. Department of Orthopaedic Surgery, St. Vincent's University Hospital, Dublin, Ireland.

PMID: 34901333 PMCID: PMC8640873 DOI: 10.1016/j.bonr.2021.101142

Abstract

Tumor-induced osteomalacia (TIO) is an ultrarare disorder that is caused by renal phosphate wasting due to uncontrolled tumoral production of fibroblast growth factor 23 (FGF23) from phosphaturic mesenchymal tumors. Surgical removal of the tumor is curative. There is limited information on the biochemical changes in mineral metabolism and bone remodeling activity after surgery, but it is reported that surgery is followed by a hungry bone syndrome (HBS) with hypocalcemia and secondary hyperparathyroidism. We report the biochemical response to surgery in two patients, who presented with severe TIO, as manifested by proximal myopathy, multiple stress fractures, high FGF23, low serum phosphate, low maximum renal phosphate reabsorption threshold (TmP/GFR), and low 1,25-dihydroxy-vitamin D (1,25(OH)

© 2021 The Authors.

Keywords: High bone turnover; Hungry bone syndrome; Hyperparathyroidism; Surgery; Tumor-induced osteomalacia

Conflict of interest statement

MMcK received fees for lectures or advice from: Amgen, Clonmel Healthcare, Mylan, Pharmacosmos, and UCB. None of the other authors have any conflicts of interest.

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