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Kerzner J, Liu H, Demchenko I, et al. Stellate Ganglion Block for Psychiatric Disorders: A Systematic Review of the Clinical Research Landscape. Chronic Stress (Thousand Oaks). 2021;5:24705470211055176doi: 10.1177/24705470211055176.
Kerzner, J., Liu, H., Demchenko, I., Sussman, D., Wijeysundera, D. N., Kennedy, S. H., Ladha, K. S., & Bhat, V. (2021). Stellate Ganglion Block for Psychiatric Disorders: A Systematic Review of the Clinical Research Landscape. Chronic stress (Thousand Oaks, Calif.), 524705470211055176. https://doi.org/10.1177/24705470211055176
Kerzner, Jaimie, et al. "Stellate Ganglion Block for Psychiatric Disorders: A Systematic Review of the Clinical Research Landscape." Chronic stress (Thousand Oaks, Calif.) vol. 5 (2021): 24705470211055176. doi: https://doi.org/10.1177/24705470211055176
Kerzner J, Liu H, Demchenko I, Sussman D, Wijeysundera DN, Kennedy SH, Ladha KS, Bhat V. Stellate Ganglion Block for Psychiatric Disorders: A Systematic Review of the Clinical Research Landscape. Chronic Stress (Thousand Oaks). 2021 Dec 08;5:24705470211055176. doi: 10.1177/24705470211055176. eCollection 2021. PMID: 34901677; PMCID: PMC8664306.
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Chronic Stress (Thousand Oaks). 2021 Dec 08;5:24705470211055176. doi: 10.1177/24705470211055176. eCollection 2021.

Stellate Ganglion Block for Psychiatric Disorders: A Systematic Review of the Clinical Research Landscape.

Chronic stress (Thousand Oaks, Calif.)

Jaimie Kerzner, Helen Liu, Ilya Demchenko, David Sussman, Duminda N Wijeysundera, Sidney H Kennedy, Karim S Ladha, Venkat Bhat

Affiliations

  1. Interventional Psychiatry Program, Psychiatric Health and Addictions Service, St. Michael's Hospital, Toronto, Ontario, Canada.
  2. Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.
  3. Department of Anesthesia, St. Michael's Hospital, Toronto, Ontario, Canada.
  4. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
  5. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  6. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

PMID: 34901677 PMCID: PMC8664306 DOI: 10.1177/24705470211055176

Abstract

Stellate ganglion block (SGB) is a procedure involving the injection of a local anesthetic surrounding the stellate ganglion to inhibit sympathetic outflow. The objective of this review was to summarize existing evidence on the use of SGB in adults with psychiatric disorders. A systematic search identified 17 published studies and 4 registered clinical trials. Eighty-eight percent of published studies, including 2 randomized controlled trials (RCTs), used SGB for posttraumatic stress disorder (PTSD), although its use for schizophrenia spectrum disorders was also explored. Administration of 1 to 2 SGBs using right-sided laterality with 0.5% ropivacaine was most common. Preliminary evidence from clinical trials and case studies supports the feasibility of SGB for treating psychiatric disorders involving dysregulation of the sympathetic nervous system, although effectiveness evidence from RCTs is mixed. One RCT concluded that improvement in PTSD symptoms was significant, while the other concluded that it was nonsignificant. Improvements were noted within 5 minutes of SGB and lasted 1 month or longer. Registered clinical trials are exploring the use of SGB in new psychiatric disorders, including major depressive disorder and borderline personality disorder. More studies with larger sample sizes and alternate protocols are needed to further explore therapeutic potential of SGB for psychiatric disorders.

© The Author(s) 2021.

Keywords: anesthesia; autonomic nerve block; posttraumatic stress disorder; psychiatric disorders; stellate ganglion; stellate ganglion block; sympathetic nervous system; sympatholytics; systematic review

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Kerzner, Liu, S

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