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Mousapour P, Barzin M, Valizadeh M, et al. Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: a gender-stratified 15.5-year follow-up. BMC Public Health. 2021;21(1):2276doi: 10.1186/s12889-021-12371-7.
Mousapour, P., Barzin, M., Valizadeh, M., Mahdavi, M., Hadaegh, F., Azizi, F., & Hosseinpanah, F. (2021). Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: a gender-stratified 15.5-year follow-up. BMC public health, 21(1), 2276. https://doi.org/10.1186/s12889-021-12371-7
Mousapour, Pouria, et al. "Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: a gender-stratified 15.5-year follow-up." BMC public health vol. 21,1 (2021): 2276. doi: https://doi.org/10.1186/s12889-021-12371-7
Mousapour P, Barzin M, Valizadeh M, Mahdavi M, Hadaegh F, Azizi F, Hosseinpanah F. Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: a gender-stratified 15.5-year follow-up. BMC Public Health. 2021 Dec 13;21(1):2276. doi: 10.1186/s12889-021-12371-7. PMID: 34903195.
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BMC Public Health. 2021 Dec 13;21(1):2276. doi: 10.1186/s12889-021-12371-7.

Wrist circumference as a novel predictor of transition from metabolically healthy to unhealthy phenotype in overweight/obese adults: a gender-stratified 15.5-year follow-up.

BMC public health

Pouria Mousapour, Maryam Barzin, Majid Valizadeh, Maryam Mahdavi, Farzad Hadaegh, Fereidoun Azizi, Farhad Hosseinpanah

Affiliations

  1. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  2. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  3. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  4. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [email protected].

PMID: 34903195 DOI: 10.1186/s12889-021-12371-7

Abstract

BACKGROUND: Individuals with transition from metabolically healthy overweight/obese (MHO) to metabolically unhealthy overweight/obese (MUO) phenotype are significantly predisposed to greater risks of cardiovascular events compared to those with a persistent MHO phenotype. The aim of this study was to evaluate the predictive performance of wrist circumference for this transition in adults over a 15.5-year follow-up.

METHODS: We included 309 males and 821 females with the age of ≥18 years old, body mass index ≥25 kg/m

RESULTS: The overall rate of transition from MHO to MUO phenotype was 87.1% in males and 77.5% in females. The hazard ratios (HRs) with 95% CI across second and third tertiles of wrist circumference were 0.89 (0.64-1.24) and 1.31 (0.99-1.73) in men (P for trend =0.027); and 1.34 (1.09-1.66) and 1.61 (1.30-2.00) in women (P for trend <0.001), respectively. After multivariable adjustment, HRs across second and third tertiles of wrist circumference were 0.92 (0.64-1.32) and 1.18 (0.83-1.67) in males (p for trend =0.352), and 1.32 (1.05-1.65) and 1.34 (1.06-1.96) in females (p for trend =0.025), respectively.

CONCLUSIONS: Wrist circumference significantly predicts the transition from MHO to MUO phenotype in adults of both genders. However, it is an independent predictor of the transition only in females. Future studies are warranted to clarify the role of wrist circumference mechanisms on metabolic risk deterioration.

© 2021. The Author(s).

Keywords: Gender; Metabolically healthy obesity; Metabolically unhealthy obesity; Transition; Wrist circumference

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