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RNA Biol. 2021 Oct 15;18:337-354. doi: 10.1080/15476286.2021.1947648. Epub 2021 Aug 04.

Annexin A2 binds the internal ribosomal entry site of c-.

RNA biology

Elin Strand, Hanne Hollås, Siri Aastedatter Sakya, Sofya Romanyuk, Mikko E V Saraste, Ann Kari Grindheim, Sudarshan S Patil, Anni Vedeler

Affiliations

  1. Department of Biomedicine, University of Bergen, Bergen, Norway.
  2. Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.
  3. Department of Pharmacology, Institute of Clinical Medicine, University of Oslo, Norway.
  4. City Hospital ?40, St. Petersburg, Russia.
  5. Quality Control Unit, Thermo Fisher Scientific - Life Technologies, Lillestrøm, Norway.

PMID: 34346292 DOI: 10.1080/15476286.2021.1947648

Abstract

The expression and localization of the oncoprotein c-Myc is highly regulated at the level of transcription, mRNA transport, translation, as well as stability of the protein. We previously showed that Annexin A2 (AnxA2) binds to a specific localization element in the 3'untranslated region (UTR) of c-

Keywords: Annexin A2; IRES; ITAFS; c-Myc; calcium; forskolin; translation

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