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RNA Biol. 2021 Oct 15;18:19-30. doi: 10.1080/15476286.2021.1969113. Epub 2021 Aug 23.

Interplays of different types of epitranscriptomic mRNA modifications.

RNA biology

Praveenkumar Rengaraj, Aleš Obrdlík, Dragana Vukić, Nandan Mysore Varadarajan, Liam P Keegan, Štěpánka Vaňáčová, Mary A O'Connell

Affiliations

  1. Central European Institute of Technology (CEITEC), CEITEC, Masaryk University Brno, Brno, Czech Republic.

PMID: 34424827 DOI: 10.1080/15476286.2021.1969113

Abstract

Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m

Keywords: ADAR; Inosine; epitranscriptome; m1A; m5C; m6A; m6Am; pseudouridine

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