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Rezaeimanesh N, Moghadasi AN, Sahraian MA, et al. Dietary risk factors of primary progressive multiple sclerosis: A population-based case-control study. Mult Scler Relat Disord. 2021;56:103233doi: 10.1016/j.msard.2021.103233.
Rezaeimanesh, N., Moghadasi, A. N., Sahraian, M. A., & Eskandarieh, S. (2021). Dietary risk factors of primary progressive multiple sclerosis: A population-based case-control study. Multiple sclerosis and related disorders, 56103233. https://doi.org/10.1016/j.msard.2021.103233
Rezaeimanesh, Nasim, et al. "Dietary risk factors of primary progressive multiple sclerosis: A population-based case-control study." Multiple sclerosis and related disorders vol. 56 (2021): 103233. doi: https://doi.org/10.1016/j.msard.2021.103233
Rezaeimanesh N, Moghadasi AN, Sahraian MA, Eskandarieh S. Dietary risk factors of primary progressive multiple sclerosis: A population-based case-control study. Mult Scler Relat Disord. 2021 Nov;56:103233. doi: 10.1016/j.msard.2021.103233. Epub 2021 Aug 31. PMID: 34488182.
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Mult Scler Relat Disord. 2021 Nov;56:103233. doi: 10.1016/j.msard.2021.103233. Epub 2021 Aug 31.

Dietary risk factors of primary progressive multiple sclerosis: A population-based case-control study.

Multiple sclerosis and related disorders

Nasim Rezaeimanesh, Abdorreza Naser Moghadasi, Mohammad Ali Sahraian, Sharareh Eskandarieh

Affiliations

  1. Multiple Sclerosis Research Center, Neuroscience Institute, University of Medical Sciences, Tehran, Iran.
  2. Multiple Sclerosis Research Center, Neuroscience Institute, University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

PMID: 34488182 DOI: 10.1016/j.msard.2021.103233

Abstract

OBJECTIVES: There are growing evidences on the role of nutritional factors in multiple sclerosis (MS) occurrence. But dietary data are limited in primary progressive type of MS (PPMS). We assessed the role of dietary factors during adolescence in PPMS risk.

METHODS: An incident case-control study on 143 PPMS cases with definite diagnosis and 400 controls were conducted in Sina hospital, Tehran, Iran. Demographic data were collected. Data on nutritional habits during adolescence were obtained using questionnaire designed for multinational case-control studies of environmental risk factors for multiple sclerosis (EnvIMS-Q). Logistic regression models were run to evaluate the role of diet in PPMS risk.

RESULTS: A significant association was founded between higher intake of dairy, seafood, red meat, poultry, vegetable, fruit and nut and lower risk of PPMS (P< 00.5). This association was dose dependent for all mentioned food groups except fruit. In the fully adjusted model, more intake of dairy (OR: 0.27; 95%CI: 0.14-0.53), seafood (OR: 0.21; 95%CI: 0.10-0.44), red meat (OR:0.44; 95%CI: 0.22-0.90), vegetable (OR: 0.19; 95%CI: 0.09-0.39), fruit (OR: 0.47; 95%CI: 0.22-0.99) and nut (OR: 0.29; 95%CI: 0.15-0.56) in the third tertiles resulted in significant reduction in PPMS risk. In case of poultry consumption, the association was meaningful just in the third tertile of crude model (OR: 0.54; 95%CI: 0.30-0.95). Nutrient supplementation with calcium, iron, folic acid, vitamin B12 and C were also related with more than 84% lower risk of PPMS.

CONCLUSION: Our data proposed that adequate intake of food groups and nutrient supplementation during adolescence may be effective in reducing adult-onset PPMS risk.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Case-control; Diet; Primary progressive multiple sclerosis; Risk

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