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Rasoul AA, Khudhur ZO, Hamad MS, et al. The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish population. Mult Scler Relat Disord. 2021;56:103228doi: 10.1016/j.msard.2021.103228.
Rasoul, A. A., Khudhur, Z. O., Hamad, M. S., Ismaeal, Y. S., Smail, S. W., Rasul, M. F., Mohammad, K. A., Bapir, A. A., Omar, S. A., Qadir, M. K., Rajab, M. F., Salihi, A., Kaleem, M., Rizwan, M. A., Qureshi, A. S., Iqbal, Z. M., & Qudratullah. (2021). The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish population. Multiple sclerosis and related disorders, 56103228. https://doi.org/10.1016/j.msard.2021.103228
Rasoul, Abdulrahman Aziz, et al. "The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish population." Multiple sclerosis and related disorders vol. 56 (2021): 103228. doi: https://doi.org/10.1016/j.msard.2021.103228
Rasoul AA, Khudhur ZO, Hamad MS, Ismaeal YS, Smail SW, Rasul MF, Mohammad KA, Bapir AA, Omar SA, Qadir MK, Rajab MF, Salihi A, Kaleem M, Rizwan MA, Qureshi AS, Iqbal ZM, Qudratullah. The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish population. Mult Scler Relat Disord. 2021 Nov;56:103228. doi: 10.1016/j.msard.2021.103228. Epub 2021 Aug 28. PMID: 34492630.
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Mult Scler Relat Disord. 2021 Nov;56:103228. doi: 10.1016/j.msard.2021.103228. Epub 2021 Aug 28.

The role of oxidative stress and haematological parameters in relapsing-remitting multiple sclerosis in Kurdish population.

Multiple sclerosis and related disorders

Abdulrahman Aziz Rasoul, Zhikal Omar Khudhur, Majeed Salih Hamad, Younis Sadiq Ismaeal, Shukur Wasman Smail, Mohammed Fatih Rasul, Karzan Abdulmuhsin Mohammad, Ahmed Abdulrazzaq Bapir, Shwan Ali Omar, Mahdi Khaled Qadir, Mustafa Fahmi Rajab, Abbas Salihi, Muhammad Kaleem, Muhammad Arif Rizwan, Anas Sarwar Qureshi, Zeeshan Muhammad Iqbal, Qudratullah

Affiliations

  1. Kurdistan Board of Medical Specialties (KBMS), Kurdistan Region, Iraq.
  2. Department of Medical Analysis, Faculty of Science, Tishk International University - Erbil, Kurdistan Region, Iraq.
  3. College of Medicine, Hawler Medical University, Kurdistan Region, Iraq.
  4. College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq.
  5. Biology Department, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq; Department of Biology, College of Science, Cihan University-Erbil, Kurdistan Region, Iraq. Electronic address: [email protected].
  6. General Directorate for Scientific Research Center, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.
  7. Awamedica Pharmaceutical Company-Erbil, Iraq.
  8. Ministry of Health, Kurdistan Regional Government, Erbil, Iraq.
  9. Department of Physiotherapy, Erbil Technical Health College, Erbil Polytechnic University, Erbil, Iraq.
  10. Biology Department, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq.
  11. Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.
  12. Department of Anatomy, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
  13. Department of Livestock Management, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.
  14. Department of Surgery, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. Electronic address: [email protected].

PMID: 34492630 DOI: 10.1016/j.msard.2021.103228

Abstract

BACKGROUND: Multiple sclerosis (MS), as a neurodegenerative disorder, exhibits inflammation and oxidative stress hallmarks.

OBJECTIVE: The research aims to know any disturbances in haematological parameters and antioxidant system of relapsing-remitting multiple sclerosis (RRMS) patients in the Kurdish population.

METHODS: A case-control research meeting following the McDonald criterion was conducted on 100 RRMS patients and 100 controls.

RESULTS: Lipid peroxidation products of malondialdehyde (MDA), erythrocyte sedimentation rate (ESR), and total leucocyte counts (TLCs) were increased significantly, but copper (Cu+2) and superoxide dismutase (SOD) were decreased significantly while nitric oxide metabolites (NOx) and lymphocyte were not changed significantly if compared with that of controls.

CONCLUSION: Findings from our study revealed that some defects were detected in haematological profiles in the Kurdish population and disturbance of immunological parameters. In addition, the utilization of Cu+2 supplement as an effective modality for RRMS patients may be beneficial.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: And relapsing-remitting multiple sclerosis; Erythrocyte sedimentation rate; Hematological parameters; Inflammation; Oxidative stress

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