Display options
Cite
Shaw TD, Krasnodembskaya AD, Schroeder GN, et al. Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases. Clin Microbiol Rev. 2021;34(4):e0006421doi: 10.1128/CMR.00064-21.
Shaw, T. D., Krasnodembskaya, A. D., Schroeder, G. N., Zumla, A., Maeurer, M., & O'Kane, C. M. (2021). Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases. Clinical microbiology reviews, 34(4), e0006421. https://doi.org/10.1128/CMR.00064-21
Shaw, Timothy D, et al. "Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases." Clinical microbiology reviews vol. 34,4 (2021): e0006421. doi: https://doi.org/10.1128/CMR.00064-21
Shaw TD, Krasnodembskaya AD, Schroeder GN, Zumla A, Maeurer M, O'Kane CM. Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases. Clin Microbiol Rev. 2021 Dec 15;34(4):e0006421. doi: 10.1128/CMR.00064-21. Epub 2021 Oct 06. PMID: 34612662; PMCID: PMC8510528.
Copy Download .nbib Format: NLM
Share it on

Clin Microbiol Rev. 2021 Dec 15;34(4):e0006421. doi: 10.1128/CMR.00064-21. Epub 2021 Oct 06.

Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases.

Clinical microbiology reviews

Timothy D Shaw, Anna D Krasnodembskaya, Gunnar N Schroeder, Alimuddin Zumla, Markus Maeurer, Cecilia M O'Kane

Affiliations

  1. Wellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, United Kingdom.
  2. Center for Clinical Microbiology, Division of Infection and Immunity, University College Londongrid.83440.3b, NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom.
  3. Immunosurgery Unit, Champalimaud Centre for the Unknown, Lisbon, Portugal.
  4. Department of Oncology and Haematology, Krankenhaus Nordwest, Frankfurt, Germany.

PMID: 34612662 PMCID: PMC8510528 DOI: 10.1128/CMR.00064-21

Abstract

There is an urgent need for new antimicrobial strategies for treating complex infections and emerging pathogens. Human mesenchymal stromal cells (MSCs) are adult multipotent cells with antimicrobial properties, mediated through direct bactericidal activity and modulation of host innate and adaptive immune cells. More than 30

Keywords: antimicrobial; cell therapy; clinical trials; host-directed therapy; immunomodulation; immunotherapy; infectious diseases; mesenchymal stromal cells; pathogens

Publication Types

Grant support