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Sangnes DA, Lundervold K, Bekkelund M, et al. Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls. United European Gastroenterol J. 2021;9(10):1168-1177doi: 10.1002/ueg2.12169.
Sangnes, D. A., Lundervold, K., Bekkelund, M., von Volkmann, H. L., Berentsen, B., Gilja, O. H., Dimcevski, G., & Søfteland, E. (2021). Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls. United European gastroenterology journal, 9(10), 1168-1177. https://doi.org/10.1002/ueg2.12169
Sangnes, Dag A, et al. "Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls." United European gastroenterology journal vol. 9,10 (2021): 1168-1177. doi: https://doi.org/10.1002/ueg2.12169
Sangnes DA, Lundervold K, Bekkelund M, von Volkmann HL, Berentsen B, Gilja OH, Dimcevski G, Søfteland E. Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls. United European Gastroenterol J. 2021 Dec;9(10):1168-1177. doi: 10.1002/ueg2.12169. Epub 2021 Oct 23. PMID: 34687494.
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United European Gastroenterol J. 2021 Dec;9(10):1168-1177. doi: 10.1002/ueg2.12169. Epub 2021 Oct 23.

Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls.

United European gastroenterology journal

Dag A Sangnes, Katarina Lundervold, Mattis Bekkelund, Hilde L von Volkmann, Birgitte Berentsen, Odd Helge Gilja, Georg Dimcevski, Eirik Søfteland

Affiliations

  1. Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  2. Department of Clinical Medicine, University of Bergen, Bergen, Norway.
  3. The National Centre for Functional Gastrointestinal Disorders, Haukeland University Hospital, Bergen, Norway.
  4. National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
  5. Department of Neurology, Haukeland University Hospital, Bergen, Norway.
  6. Department of Clinical Medicine, University of Oslo, Oslo, Norway.
  7. Department of Clinical Science, University of Bergen, Bergen, Norway.
  8. Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.

PMID: 34687494 DOI: 10.1002/ueg2.12169

Abstract

BACKGROUND: Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there is a need for better diagnostic understanding of the condition.

OBJECTIVE: In this wireless motility capsule study, we aimed to investigate gastrointestinal transit and contractility in diabetes patients with and without constipation, and in healthy controls.

METHODS: We prospectively included type 1 or type 2 diabetes patients with gastrointestinal symptoms. Based on the Gastrointestinal Symptom Rating Scale we distinguished into two groups: with constipation and without constipation. Non-diabetic controls were asymptomatic. All were examined with wireless motility capsule, determining transit times and contractility parameters.

RESULTS: 57 patients (42 women, 46 with type 1 diabetes) and 26 healthy controls (14 women) were included. We found no difference in transit times between diabetes patients with and without constipation. Compared to healthy controls (35:55, h:min), whole-gut transit was slower in both diabetes patients with constipation (66:15, p = 0.03) and without constipation (71:16, p < 0.001). Small bowel motility index correlated r

CONCLUSIONS: Diabetes patients with constipation had similar transit times as those without constipation. Both groups had slower whole-gut transit than healthy controls. Constipation was associated with reduced small bowel, but not colonic contractility. Our results imply that other mechanisms than slow colonic transit may be more important in the pathogenesis of diabetic constipation.

© 2021 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.

Keywords: constipation; diabetes mellitus; gastroenteropathy; motility; transit; wireless motility capsule

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