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Beydoun MA, Noren Hooten N, Maldonado AI, et al. Body Mass Index and Allostatic Load are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light Among Urban Middle-aged Adults. J Nutr. 2021;doi: 10.1093/jn/nxab381.
Beydoun, M. A., Noren Hooten, N., Maldonado, A. I., Beydoun, H. A., Weiss, J., Evans, M. K., & Zonderman, A. B. (2021). Body Mass Index and Allostatic Load are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light Among Urban Middle-aged Adults. The Journal of nutrition, . https://doi.org/10.1093/jn/nxab381
Beydoun, May A, et al. "Body Mass Index and Allostatic Load are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light Among Urban Middle-aged Adults." The Journal of nutrition vol. (2021). doi: https://doi.org/10.1093/jn/nxab381
Beydoun MA, Noren Hooten N, Maldonado AI, Beydoun HA, Weiss J, Evans MK, Zonderman AB. Body Mass Index and Allostatic Load are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light Among Urban Middle-aged Adults. J Nutr. 2021 Oct 29; doi: 10.1093/jn/nxab381. Epub 2021 Oct 29. PMID: 34718678.
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J Nutr. 2021 Oct 29; doi: 10.1093/jn/nxab381. Epub 2021 Oct 29.

Body Mass Index and Allostatic Load are Directly Associated with Longitudinal Increase in Plasma Neurofilament Light Among Urban Middle-aged Adults.

The Journal of nutrition

May A Beydoun, Nicole Noren Hooten, Ana I Maldonado, Hind A Beydoun, Jordan Weiss, Michele K Evans, Alan B Zonderman

Affiliations

  1. Laboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD.
  2. Department of Psychology, University of Maryland, Baltimore County, Catonsville, MD.
  3. Department of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, VA.
  4. Department of Demography, University of California, Berkeley, Berkeley, CA.

PMID: 34718678 DOI: 10.1093/jn/nxab381

Abstract

BACKGROUND: Plasma neurofilament light, a novel biomarker for age-related neurodegenerative disease, may be linked to cardiometabolic risk factors, including body mass index (BMI), the allostatic load total score (ALtotal) and related continuous components (ALcomp). These relationships may differ by sex and race.

METHODS: We used data from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study [n = 608, Age at visit 1 (v1:2004-2009): 30-66y, 42% male, 58% African American] to investigate associations of initial cardiometabolic risk factors and time-dependent plasma NfL levels over 3 visits (2004-2017; mean follow-up time±SD:7.72±1.28y), with outcomes being NfLv1 and annualized change in NfL (δNfL). We used mixed-effects linear regression and structural equations modeling (SM).

RESULTS: BMI was associated with lower initial (γ01 = -0.014±0.002, P<0.001) but faster increase in plasma NfL over time (γ11 = +0.0012±0.0003, P<0.001), a pattern replicated for ALtotal. High sensitivity C-reactive protein (hsCRP), serum total cholesterol, and resting heart rate at v1 were linked with faster plasma NfL over-time increase overall, while being uncorrelated with NfLv1 (e.g. hsCRP×TIME, full model: γ11 = +0.004±0.002, P = 0.015). In SM analyses, BMI's association with δNfL was significantly mediated through ALtotal among women (Total effect = +0.0014±0.00038, P<0.001; Indirect effect = +0.00042±0.00019, P = 0.025; mediation proportion = 30%), with only a direct effect detected among African Americans (Total (effect = +0.0011±0.0004, P = 0.015; Direct effect = +0.0010±0.00048, P = 0.034). The positive associations between ALtotal/BMI and δNfL were mediated through increased HbA1c levels, overall.

CONCLUSIONS: Cardiometabolic risk factors, particularly elevated HbA1c, should be screened and targeted for neurodegenerative disease, pending comparable longitudinal studies. Other studies examining the clinical utility of plasma NfL as a neurodegeneration marker should account for confounding effects of BMI and AL.

Published by Oxford University Press on behalf of the American Society for Nutrition 2021.

Keywords: Neurofilament light; allostatic load; body mass index; cognition; race; urban adults

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