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Yi J, Chung JW, Pak JH. Zinc is an essential element for the maintenance of redox homeostasis and cell cycle in murine auditory hair cells. J Nutr Biochem. 2021;100:108901doi: 10.1016/j.jnutbio.2021.108901.
Yi, J., Chung, J. W., & Pak, J. H. (2021). Zinc is an essential element for the maintenance of redox homeostasis and cell cycle in murine auditory hair cells. The Journal of nutritional biochemistry, 100108901. https://doi.org/10.1016/j.jnutbio.2021.108901
Yi, Junyeong, et al. "Zinc is an essential element for the maintenance of redox homeostasis and cell cycle in murine auditory hair cells." The Journal of nutritional biochemistry vol. 100 (2021): 108901. doi: https://doi.org/10.1016/j.jnutbio.2021.108901
Yi J, Chung JW, Pak JH. Zinc is an essential element for the maintenance of redox homeostasis and cell cycle in murine auditory hair cells. J Nutr Biochem. 2021 Nov 05;100:108901. doi: 10.1016/j.jnutbio.2021.108901. Epub 2021 Nov 05. PMID: 34748925.
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J Nutr Biochem. 2021 Nov 05;100:108901. doi: 10.1016/j.jnutbio.2021.108901. Epub 2021 Nov 05.

Zinc is an essential element for the maintenance of redox homeostasis and cell cycle in murine auditory hair cells.

The Journal of nutritional biochemistry

Junyeong Yi, Jong Woo Chung, Jhang Ho Pak

Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical Center, Songpa-Gu, Seoul, Korea. Electronic address: [email protected].
  2. Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulsan College of Medicine, Asan Medical Center, Songpa-Gu, Seoul, Korea. Electronic address: [email protected].
  3. Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Asan Medical Center, Songpa-Gu, Seoul, Korea. Electronic address: [email protected].

PMID: 34748925 DOI: 10.1016/j.jnutbio.2021.108901

Abstract

A nutrition deficiency is one of the various causes of hearing loss. Zinc is an essential element for cell proliferation, antioxidant reactions, and the maintenance of hearing ability. Our previous studies have reported that the auditory brainstem response (ABR) threshold is increased in mice fed with zinc-deficient diets. However, the molecular mechanism of zinc involved in auditory system remains to be elucidated. In the present study, we examined the detrimental effects of zinc deficiency on cell cycle progression in murine auditory cells (HEI-OC1). The treatment of HEI-OC1 cells with 0.5 μM TPEN (N,N,N',N'-Tetrakis (2-pyridylmethyl) ethylenediamine) for 24 h inhibited cell proliferation, accumulation of reactive oxygen species (ROS), and induction of apoptosis. The cell proliferation block was caused by a G1/S phase arrest. Supplementation of the cell growth medium with 5 μM ZnCl

Copyright © 2021. Published by Elsevier Inc.

Keywords: Hearing loss; cell cycle arrest; cochlea; mouse auditory hair cells; zinc deficiency

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