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Blackshaw K, Wu J, Proschogo N, et al. The effect of thermal pasteurization, freeze-drying, and gamma irradiation on donor human milk. Food Chem. 2021;373:131402doi: 10.1016/j.foodchem.2021.131402.
Blackshaw, K., Wu, J., Proschogo, N., Davies, J., Oldfield, D., Schindeler, A., Banati, R. B., Dehghani, F., & Valtchev, P. (2022). The effect of thermal pasteurization, freeze-drying, and gamma irradiation on donor human milk. Food chemistry, 373131402. https://doi.org/10.1016/j.foodchem.2021.131402
Blackshaw, Katherine, et al. "The effect of thermal pasteurization, freeze-drying, and gamma irradiation on donor human milk." Food chemistry vol. 373 (2022): 131402. doi: https://doi.org/10.1016/j.foodchem.2021.131402
Blackshaw K, Wu J, Proschogo N, Davies J, Oldfield D, Schindeler A, Banati RB, Dehghani F, Valtchev P. The effect of thermal pasteurization, freeze-drying, and gamma irradiation on donor human milk. Food Chem. 2022 Mar 30;373:131402. doi: 10.1016/j.foodchem.2021.131402. Epub 2021 Oct 14. PMID: 34741965.
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Food Chem. 2022 Mar 30;373:131402. doi: 10.1016/j.foodchem.2021.131402. Epub 2021 Oct 14.

The effect of thermal pasteurization, freeze-drying, and gamma irradiation on donor human milk.

Food chemistry

Katherine Blackshaw, Jiadai Wu, Nicholas Proschogo, Justin Davies, Daniel Oldfield, Aaron Schindeler, Richard B Banati, Fariba Dehghani, Peter Valtchev

Affiliations

  1. School of Chemical and Biomolecular Engineering, Faculty of Engineering, The University of Sydney, Sydney, NSW 2006, Australia; Centre for Advanced Food Engineering, The University of Sydney, Sydney, NSW 2006, Australia.
  2. Mass Spectrometry Facility, School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
  3. Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW 2234, Australia.
  4. School of Chemical and Biomolecular Engineering, Faculty of Engineering, The University of Sydney, Sydney, NSW 2006, Australia; Centre for Advanced Food Engineering, The University of Sydney, Sydney, NSW 2006, Australia; Bioengineering and Molecular Medicine Laboratory, The Children's Hospital at Westmead and Westmead Institute for Medical Research, Westmead, NSW 2145, Australia.
  5. Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW 2234, Australia; Faculty of Medicine and Health, Medical Imaging Sciences, Brain and Mind Centre, University of Sydney, Camperdown, NSW 2006, Australia; Mothers Milk Bank Charity (Human Milk Emergency Reserve-Project), Australia. Electronic address: [email protected].

PMID: 34741965 DOI: 10.1016/j.foodchem.2021.131402

Abstract

The availability of donor human milk (DHM) is currently limited by the volumes that can be thermally pasteurized and kept in long-term cold storage. This study assesses the application of freeze-drying followed by low-dose gamma irradiation of DHM for simplified, safe long-term storage. Solid-phase microextraction (SPME) GC-MS, SDS and native PAGE gel electrophoresis demonstrated that the overall changes in volatile and protein profiles in Holder pasteurized and freeze-dried DHM was negligible compared to the natural variations in DHM. Freeze-dried DHM samples (moisture < 2.2 %) processed with 2 kGy gamma irradiation did not show any significant lipid oxidation end-products and variation in protein profile. Therefore, freeze-drying followed by in-packaging gamma irradiation could be a safe method for pasteurization, convenient storage and delivery of DHM at ambient temperature. These methods may generate a means to create a reserve stock of DHM for emergencies and humanitarian aid.

Copyright © 2021. Published by Elsevier Ltd.

Keywords: Donor human milk; Emergency preparedness; Freeze-drying; Gamma irradiation; Holder pasteurization; Lyophilization; SPME-GC–MS; Terminal sterilization

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