Display options
Cite
Manigrasso MB, Rabbani P, Egaña-Gorroño L, et al. Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Sci Transl Med. 2021;13(621):eabf7084doi: 10.1126/scitranslmed.abf7084.
Manigrasso, M. B., Rabbani, P., Egaña-Gorroño, L., Quadri, N., Frye, L., Zhou, B., Reverdatto, S., Ramirez, L. S., Dansereau, S., Pan, J., Li, H., D'Agati, V. D., Ramasamy, R., DeVita, R. J., Shekhtman, A., & Schmidt, A. M. (2021). Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Science translational medicine, 13(621), eabf7084. https://doi.org/10.1126/scitranslmed.abf7084
Manigrasso, Michaele B, et al. "Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice." Science translational medicine vol. 13,621 (2021): eabf7084. doi: https://doi.org/10.1126/scitranslmed.abf7084
Manigrasso MB, Rabbani P, Egaña-Gorroño L, Quadri N, Frye L, Zhou B, Reverdatto S, Ramirez LS, Dansereau S, Pan J, Li H, D'Agati VD, Ramasamy R, DeVita RJ, Shekhtman A, Schmidt AM. Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Sci Transl Med. 2021 Nov 24;13(621):eabf7084. doi: 10.1126/scitranslmed.abf7084. Epub 2021 Nov 24. PMID: 34818060; PMCID: PMC8669775.
Copy Download .nbib Format: NLM
Share it on

Sci Transl Med. 2021 Nov 24;13(621):eabf7084. doi: 10.1126/scitranslmed.abf7084. Epub 2021 Nov 24.

Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice.

Science translational medicine

Michaele B Manigrasso, Piul Rabbani, Lander Egaña-Gorroño, Nosirudeen Quadri, Laura Frye, Boyan Zhou, Sergey Reverdatto, Lisa S Ramirez, Stephen Dansereau, Jinhong Pan, Huilin Li, Vivette D D'Agati, Ravichandran Ramasamy, Robert J DeVita, Alexander Shekhtman, Ann Marie Schmidt

Affiliations

  1. Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, NYU Langone Health, New York, NY 10016, USA.
  2. Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY 10016, USA.
  3. Departments of Population Health (Biostatistics) and Environmental Medicine, NYU Langone Health, New York, NY 10016, USA.
  4. Department of Chemistry, State University of New York at Albany, Albany, NY 12222, USA.
  5. Department of Pathology, Columbia University Irving Medical Center, New York, NY 10032, USA.
  6. RJD Medicinal Chemistry and Drug Discovery Consulting LLC, Westfield, NJ 07091, USA.

PMID: 34818060 PMCID: PMC8669775 DOI: 10.1126/scitranslmed.abf7084

Abstract

[Figure: see text].

References

  1. Eur Cardiol. 2019 Apr;14(1):50-59 - PubMed
  2. Ther Adv Endocrinol Metab. 2018 Jan;9(1):29-31 - PubMed
  3. Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1823-32 - PubMed
  4. J Biol Chem. 2008 Oct 3;283(40):27255-69 - PubMed
  5. Med Sci Monit. 2019 Apr 25;25:3061-3068 - PubMed
  6. Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):43-49 - PubMed
  7. J Magn Reson. 2005 May;174(1):133-51 - PubMed
  8. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1199-208 - PubMed
  9. Proteins. 2005 Jun 1;59(4):687-96 - PubMed
  10. Mol Nutr Food Res. 2021 Jan;65(1):e1900482 - PubMed
  11. EBioMedicine. 2017 Dec;26:165-174 - PubMed
  12. Heart Lung Circ. 2021 Feb;30(2):186-196 - PubMed
  13. Sci Rep. 2016 Mar 03;6:22450 - PubMed
  14. Am J Kidney Dis. 2003 Jan;41(1):1-12 - PubMed
  15. Circulation. 2006 Mar 7;113(9):1226-34 - PubMed
  16. Genes Immun. 2002 May;3(3):123-35 - PubMed
  17. Front Cardiovasc Med. 2020 Mar 10;7:37 - PubMed
  18. Protein Sci. 1994 Oct;3(10):1822-32 - PubMed
  19. J Biomol NMR. 1999 Mar;13(3):289-302 - PubMed
  20. Life Sci. 2020 Jan 1;240:117090 - PubMed
  21. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1601-F1612 - PubMed
  22. Diabetes Care. 1998 May;21(5):822-7 - PubMed
  23. J Diabetes Complications. 2020 Aug;34(8):107613 - PubMed
  24. N Engl J Med. 2016 Mar 24;374(12):1145-54 - PubMed
  25. Am J Pathol. 2003 Apr;162(4):1123-37 - PubMed
  26. Lab Invest. 2017 Jul;97(7):782-791 - PubMed
  27. Cell. 1999 Jun 25;97(7):889-901 - PubMed
  28. Diabetes Care. 2014;37(1):9-16 - PubMed
  29. Life Sci. 2019 Oct 1;234:116776 - PubMed
  30. Ann Vasc Dis. 2018 Sep 25;11(3):253-258 - PubMed
  31. J Exp Med. 2005 Feb 7;201(3):473-84 - PubMed
  32. Postgrad Med. 2018 Mar;130(2):149-153 - PubMed
  33. Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):163-74 - PubMed
  34. J Clin Invest. 2003 Apr;111(7):959-72 - PubMed
  35. Atherosclerosis. 2019 Sep;288:60-66 - PubMed
  36. Nature. 2000 May 18;405(6784):354-60 - PubMed
  37. N Engl J Med. 2017 Aug 17;377(7):644-657 - PubMed
  38. N Engl J Med. 2013 Oct 3;369(14):1317-26 - PubMed
  39. Nat Methods. 2008 May;5(5):401-3 - PubMed
  40. Oxid Med Cell Longev. 2017;2017:3937842 - PubMed
  41. Acta Pharmacol Sin. 2002 Nov;23(11):974-80 - PubMed
  42. J Magn Reson. 2001 Dec;153(2):262-6 - PubMed
  43. N Engl J Med. 2015 Nov 26;373(22):2117-28 - PubMed
  44. Am J Epidemiol. 1984 Aug;120(2):169-89 - PubMed
  45. Methods Mol Biol. 2004;278:353-78 - PubMed
  46. Biochim Biophys Acta. 2009 Jun;1793(6):993-1007 - PubMed
  47. Nat Chem Biol. 2015 Aug;11(8):536-41 - PubMed
  48. Biophys J. 2001 Oct;81(4):2395-402 - PubMed
  49. Am J Kidney Dis. 2014 Feb;63(2 Suppl 2):S39-62 - PubMed
  50. N Engl J Med. 2017 Aug 31;377(9):839-848 - PubMed
  51. J Clin Invest. 2008 Jan;118(1):183-94 - PubMed
  52. Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F716-F731 - PubMed
  53. J Biomol NMR. 1996 Dec;8(4):477-86 - PubMed
  54. Nature. 1996 Aug 22;382(6593):685-91 - PubMed
  55. Am J Pathol. 2001 Aug;159(2):513-25 - PubMed
  56. EMBO Rep. 2011 Apr;12(4):358-64 - PubMed
  57. Lancet. 2012 Jan 14;379(9811):165-80 - PubMed
  58. Ann Plast Surg. 2019 Dec;83(6):e96-e109 - PubMed
  59. Diabetes. 2010 Aug;59(8):2043-54 - PubMed
  60. J Pharmacol Exp Ther. 2012 Jul;342(1):71-80 - PubMed
  61. Biophys J. 2004 Apr;86(4):2517-29 - PubMed
  62. J Clin Invest. 1999 Jan;103(1):27-37 - PubMed
  63. J Exp Med. 2012 Dec 17;209(13):2339-50 - PubMed
  64. N Engl J Med. 2016 Jul 28;375(4):311-22 - PubMed
  65. J Biol Chem. 1995 Oct 27;270(43):25752-61 - PubMed
  66. Diabetes Metab Syndr. 2020 Sep - Oct;14(5):1449-1458 - PubMed
  67. Stem Cells Dev. 2018 Dec 1;27(23):1646-1657 - PubMed
  68. J Diabetes Complications. 2017 Sep;31(9):1363-1369 - PubMed
  69. Diabetes Care. 1998 Dec;21(12):2180-4 - PubMed
  70. Exp Clin Endocrinol Diabetes. 1999;107(2):119-25 - PubMed
  71. Structure. 2016 Sep 6;24(9):1509-22 - PubMed
  72. Nat Med. 2019 May;25(5):805-813 - PubMed
  73. Lancet. 2017 Oct 21;390(10105):1888-1917 - PubMed
  74. Kidney Int. 2015 Oct;88(4):722-33 - PubMed
  75. J Clin Invest. 1999 Jul;104(1):103-13 - PubMed
  76. Biochem Biophys Res Commun. 2014 Mar 28;446(1):195-200 - PubMed
  77. J Clin Invest. 2000 Apr;105(8):1117-24 - PubMed
  78. Am J Physiol Renal Physiol. 2002 Jun;282(6):F975-80 - PubMed
  79. J Clin Invest. 1996 Sep 1;98(5):1088-94 - PubMed
  80. J Clin Invest. 2006 Jan;116(1):115-24 - PubMed
  81. J Biol Chem. 2012 Feb 10;287(7):5133-44 - PubMed
  82. Diabetes. 2008 Jul;57(7):1941-51 - PubMed
  83. Drug Des Devel Ther. 2019 Aug 09;13:2769-2776 - PubMed
  84. Postgrad Med. 2018 Mar;130(2):154-158 - PubMed
  85. J Am Soc Nephrol. 2010 Sep;21(9):1533-42 - PubMed
  86. ScientificWorldJournal. 2007 May 29;7:666-85 - PubMed
  87. Circ Res. 2012 May 11;110(10):1279-93 - PubMed
  88. J Biol Chem. 2008 Dec 5;283(49):34457-68 - PubMed
  89. Am J Pathol. 1990 Jun;136(6):1235-46 - PubMed
  90. J Cell Physiol. 2019 Jun;234(6):8286-8294 - PubMed
  91. Trends Cardiovasc Med. 2017 Apr;27(3):194-202 - PubMed

Publication Types

Grant support