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Pietro GD, Stefano GD, Leone C, et al. The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons. Neurophysiol Clin. 2021;51(6):517-523doi: 10.1016/j.neucli.2021.09.001.
Pietro, G. D., Stefano, G. D., Leone, C., Lionardo, A. D., Sgrò, E., Blockeel, A. J., Caspani, O., Garcia-Larrea, L., Mouraux, A., Phillips, K. G., Treede, R. D., Valeriani, M., & Truini, A. (2021). The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons. Neurophysiologie clinique = Clinical neurophysiology, 51(6), 517-523. https://doi.org/10.1016/j.neucli.2021.09.001
Pietro, Giuseppe Di, et al. "The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons." Neurophysiologie clinique = Clinical neurophysiology vol. 51,6 (2021): 517-523. doi: https://doi.org/10.1016/j.neucli.2021.09.001
Pietro GD, Stefano GD, Leone C, Lionardo AD, Sgrò E, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Valeriani M, Truini A. The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons. Neurophysiol Clin. 2021 Dec;51(6):517-523. doi: 10.1016/j.neucli.2021.09.001. Epub 2021 Oct 28. PMID: 34756635.
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Neurophysiol Clin. 2021 Dec;51(6):517-523. doi: 10.1016/j.neucli.2021.09.001. Epub 2021 Oct 28.

The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons.

Neurophysiologie clinique = Clinical neurophysiology

Giuseppe Di Pietro, Giulia Di Stefano, Caterina Leone, Andrea Di Lionardo, Emanuele Sgrò, Anthony James Blockeel, Ombretta Caspani, Luis Garcia-Larrea, André Mouraux, Keith Geoffrey Phillips, Rolf-Detlef Treede, Massimiliano Valeriani, Andrea Truini

Affiliations

  1. Department of Human Neuroscience, University Sapienza, Rome, Italy.
  2. School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
  3. Department of Neurophysiology, Mannheim Center for translational Neuroscience (MCTN), Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.
  4. Lyon Neurosciences Center Research Unit Inserm U 1028, Pierre Wertheimer Hospital, Hospices Civils de Lyon, Lyon 1 University, Lyon, France; Pain Center, Pierre Wertheimer Hospital, Hospices Civils de Lyon, Lyon 1 University, Lyon, France.
  5. Université Catholique de Louvain, Institute of Neuroscience (IoNS), Faculty of Medicine, Bruxelles, Belgium.
  6. Neuroscience Next Generation Therapeutics, Eli Lilly and Company, Lilly Innovation Center, Cambridge, MA 02142, USA.
  7. Headache Center, Department of Neuroscience, Bambino Gesù Children's Hospital, Rome, Italy; Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark.
  8. Department of Human Neuroscience, University Sapienza, Rome, Italy. Electronic address: [email protected].

PMID: 34756635 DOI: 10.1016/j.neucli.2021.09.001

Abstract

OBJECTIVES: Although somatosensory evoked potentials (SEPs) after median nerve stimulation are widely used in clinical practice, the dorsal horn generator of the N13 SEP spinal component is not clearly understood. To verify whether wide dynamic range neurons in the dorsal horn of the spinal cord are involved in the generation of the N13 SEP, we tested the effect of heterotopic noxious conditioning stimulation, which modulates wide dynamic range neurons, on N13 SEP in healthy humans.

METHODS: In 12 healthy subjects, we performed the cold pressor test on the left foot as a heterotopic noxious conditioning stimulus to modulate wide dynamic range neurons. To verify the effectiveness of heterotopic noxious conditioning stimulation, we tested the pressure pain threshold at the thenar muscles of the right hand and recorded SEPs after right median nerve stimulation before, during and after the cold pressor test.

RESULTS: The cold pressor test increased pressure pain threshold by 15% (p = 0.04). During the cold pressor test, the amplitude of the N13 component was significantly lower than that recorded at baseline (by 25%, p = 0.04).

DISCUSSION: In this neurophysiological study in healthy humans, we showed that a heterotopic noxious conditioning stimulus significantly reduced N13 SEP amplitude. This finding suggests that the N13 SEP might be generated by the segmental postsynaptic response of dorsal horn wide dynamic range neurons.

Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Keywords: Experimental pain; Pain; Spinal cord; Wide dynamic range neurons

Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest regarding this work, which has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant a

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