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Int J Biol Macromol. 2021 Dec 15;193:1294-1300. doi: 10.1016/j.ijbiomac.2021.10.178. Epub 2021 Oct 30.

Correlation of Acinetobacter baumannii K144 and K86 capsular polysaccharide structures with genes at the K locus reveals the involvement of a novel multifunctional rhamnosyltransferase for structural synthesis.

International journal of biological macromolecules

Johanna J Kenyon, Anastasiya A Kasimova, Anastasiya N Sviridova, Anna M Shpirt, Mikhail M Shneider, Yuliya V Mikhaylova, Andrei A Shelenkov, Anastasiya V Popova, Andrei V Perepelov, Alexander S Shashkov, Andrei S Dmitrenok, Alexander O Chizov, Yuriy A Knirel

Affiliations

  1. Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology. Brisbane, Australia.
  2. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Moscow, Russia.
  3. D.I. Mendeleev University of Chemical Technology of Russia, Moscow, Russia.
  4. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Moscow, Russia. Electronic address: [email protected].
  5. M.M. Shemyakin and Y.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia.
  6. Central Scientific Research Institute of Epidemiology, Moscow, Russia.
  7. State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow, Region, Russia.

PMID: 34757131 DOI: 10.1016/j.ijbiomac.2021.10.178

Abstract

Whole genome sequence from Acinetobacter baumannii isolate Ab-46-1632 reveals a novel KL144 capsular polysaccharide (CPS) biosynthesis gene cluster, which carries genes for d-glucuronic acid (D-GlcA) and l-rhamnose (l-Rha) synthesis. The CPS was extracted from Ab-46-1632 and studied by

Copyright © 2021. Published by Elsevier B.V.

Keywords: Acinetobacter baumannii; Capsular polysaccharide; K144; K86; Multifunctional glycosyltransferase

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