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Ramphal B, Pagliaccio D, Thomas LV, et al. Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability. Cerebellum. 2021;20(6):931-937doi: 10.1007/s12311-021-01265-4.
Ramphal, B., Pagliaccio, D., Thomas, L. V., He, X., & Margolis, A. E. (2021). Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability. Cerebellum (London, England), 20(6), 931-937. https://doi.org/10.1007/s12311-021-01265-4
Ramphal, Bruce, et al. "Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability." Cerebellum (London, England) vol. 20,6 (2021): 931-937. doi: https://doi.org/10.1007/s12311-021-01265-4
Ramphal B, Pagliaccio D, Thomas LV, He X, Margolis AE. Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability. Cerebellum. 2021 Dec;20(6):931-937. doi: 10.1007/s12311-021-01265-4. Epub 2021 Apr 15. PMID: 33856654; PMCID: PMC8530438.
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Cerebellum. 2021 Dec;20(6):931-937. doi: 10.1007/s12311-021-01265-4. Epub 2021 Apr 15.

Contributions of Cerebellar White Matter Microstructure to Social Difficulty in Nonverbal Learning Disability.

Cerebellum (London, England)

Bruce Ramphal, David Pagliaccio, Lauren V Thomas, Xiaofu He, Amy E Margolis

Affiliations

  1. New York State Psychiatric Institute and Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Box 74 / Room 2403, New York, NY, 10032, USA.
  2. New York State Psychiatric Institute and Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Box 74 / Room 2403, New York, NY, 10032, USA. [email protected].

PMID: 33856654 PMCID: PMC8530438 DOI: 10.1007/s12311-021-01265-4

Abstract

Emerging evidence suggests that the cerebellum may contribute to variety of cognitive capacities, including social cognition. Nonverbal learning disability (NVLD) is characterized by visual-spatial and social impairment. Recent functional neuroimaging studies have shown that children with NVLD have altered cerebellar resting-state functional connectivity, which is associated with various symptom domains. However, little is known about cerebellar white matter microstructure in NVLD and whether it contributes to social deficits. Twenty-seven children (12 with NVLD, 15 typically developing (TD)) contributed useable diffusion tensor imaging data. Tract-based spatial statistics (TBSS) were used to quantify fractional anisotropy (FA) in the cerebellar peduncles. Parents completed the Child Behavior Checklist, providing a measure of social difficulty. Children with NVLD had greater fractional anisotropy in the left and right inferior cerebellar peduncle. Furthermore, right inferior cerebellar peduncle FA was associated with social impairment as measured by the Child Behavior Checklist Social Problems subscale. Finally, the association between NVLD diagnosis and greater social impairment was mediated by right inferior cerebellar peduncle FA. These findings provide additional evidence that the cerebellum contributes both to social cognition and to the pathophysiology of NVLD.

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords: Cerebellum; Diffusion tensor imaging; Neurodevelopment; Neuroimaging; Nonverbal learning disability

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