Display options
Cite
Rayasam A, Jullienne A, Chumak T, et al. Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and NETosis. J Cereb Blood Flow Metab. 2021;41(12):3171-3186doi: 10.1177/0271678X211032737.
Rayasam, A., Jullienne, A., Chumak, T., Faustino, J., Szu, J., Hamer, M., Ek, C. J., Mallard, C., Obenaus, A., & Vexler, Z. S. (2021). Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and NETosis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 41(12), 3171-3186. https://doi.org/10.1177/0271678X211032737
Rayasam, Aditya, et al. "Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and NETosis." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism vol. 41,12 (2021): 3171-3186. doi: https://doi.org/10.1177/0271678X211032737
Rayasam A, Jullienne A, Chumak T, Faustino J, Szu J, Hamer M, Ek CJ, Mallard C, Obenaus A, Vexler ZS. Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and NETosis. J Cereb Blood Flow Metab. 2021 Dec;41(12):3171-3186. doi: 10.1177/0271678X211032737. Epub 2021 Jul 22. PMID: 34293939; PMCID: PMC8669290.
Copy Download .nbib Format: NLM
Share it on

J Cereb Blood Flow Metab. 2021 Dec;41(12):3171-3186. doi: 10.1177/0271678X211032737. Epub 2021 Jul 22.

Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and NETosis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Aditya Rayasam, Amandine Jullienne, Tetyana Chumak, Joel Faustino, Jenny Szu, Mary Hamer, C Joakim Ek, Carina Mallard, Andre Obenaus, Zinaida S Vexler

Affiliations

  1. Department of Neurology, University California San Francisco, San Francisco, CA, USA.
  2. Department of Pediatrics, University of California Irvine, Irvine, CA, USA.
  3. Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

PMID: 34293939 PMCID: PMC8669290 DOI: 10.1177/0271678X211032737

Abstract

Stroke is among the top ten causes of death in children but has received disproportionally little attention. Cerebral arteriopathies account for up to 80% of childhood arterial ischemic stroke (CAIS) cases and are strongly predictive of CAIS recurrence and poorer outcomes. The underlying mechanisms of sensitization of neurovasculature by viral infection are undefined. In the first age-appropriate model for childhood arteriopathy-by administration of viral mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) in juvenile mice-we identified a key role of the TLR3-neutrophil axis in disrupting the structural-functional integrity of the blood-brain barrier (BBB) and distorting the developing neurovascular architecture and vascular networks. First, using an array of

Keywords: Neutrophil elastase; blood-brain barrier; neutrophil extracellular traps; sivelestat; toll-like receptor 3

References

  1. Stroke. 2016 Jan;47(1):53-9 - PubMed
  2. Neurobiol Dis. 2015 Feb;74:263-80 - PubMed
  3. Crit Care Med. 2002 May;30(5 Suppl):S214-9 - PubMed
  4. Pediatrics. 2007 Mar;119(3):495-501 - PubMed
  5. Circulation. 2006 Nov 14;114(20):2170-7 - PubMed
  6. Sci Rep. 2018 Jul 4;8(1):10102 - PubMed
  7. Neurobiol Learn Mem. 2018 Nov;155:379-389 - PubMed
  8. J Cereb Blood Flow Metab. 2006 Aug;26(8):1089-102 - PubMed
  9. Neurology. 2005 Feb 22;64(4):660-3 - PubMed
  10. J Immunol. 2014 May 15;192(10):4783-94 - PubMed
  11. Nat Rev Neurol. 2015 Apr;11(4):192-208 - PubMed
  12. Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H558-68 - PubMed
  13. Lancet Neurol. 2015 Jan;14(1):92-102 - PubMed
  14. Front Microbiol. 2018 Dec 21;9:3174 - PubMed
  15. Brain. 1997 Mar;120 ( Pt 3):435-44 - PubMed
  16. J Neurosci. 2012 Jul 11;32(28):9588-600 - PubMed
  17. Stroke. 1991 Oct;22(10):1276-83 - PubMed
  18. Stroke. 2018 Nov;49(11):2590-2596 - PubMed
  19. Transl Stroke Res. 2018 May 15;: - PubMed
  20. J Neurochem. 2001 Sep;78(5):1064-72 - PubMed
  21. J Neurosci. 2016 Mar 9;36(10):2881-93 - PubMed
  22. Nat Commun. 2020 May 19;11(1):2488 - PubMed
  23. Stroke. 2019 Mar;50(3):e42-e43 - PubMed
  24. Stroke. 2003 Nov;34(11):2543-8 - PubMed
  25. J Neurosurg. 1995 Feb;82(2):269-77 - PubMed
  26. Front Immunol. 2016 Sep 19;7:366 - PubMed
  27. Stroke. 2019 Nov;50(11):3228-3237 - PubMed
  28. J Cell Mol Med. 2015 Mar;19(3):555-65 - PubMed
  29. J Cereb Blood Flow Metab. 2020 Sep;40(9):1769-1777 - PubMed
  30. Front Immunol. 2020 Apr 21;11:516 - PubMed
  31. Brain Res. 2009 Mar 9;1259:98-106 - PubMed
  32. Nature. 2001 Oct 18;413(6857):732-8 - PubMed
  33. Acta Neuropathol. 2013 Mar;125(3):395-412 - PubMed
  34. Nat Methods. 2013 Mar;10(3):228-38 - PubMed
  35. Brain Behav Immun. 2010 Aug;24(6):996-1007 - PubMed
  36. J Neurosci. 2013 Jul 17;33(29):12041-51 - PubMed
  37. CNS Neurosci Ther. 2015 Nov;21(11):905-13 - PubMed
  38. Front Physiol. 2019 Mar 26;10:306 - PubMed
  39. J Cereb Blood Flow Metab. 2019 Oct;39(10):1919-1935 - PubMed
  40. J Neurosci Res. 1991 Jul;29(3):336-45 - PubMed
  41. Curr Opin Neurol. 2020 Feb;33(1):37-46 - PubMed
  42. Nat Immunol. 2020 Feb;21(2):135-144 - PubMed
  43. PLoS One. 2015 Oct 27;10(10):e0141746 - PubMed
  44. Circulation. 2009 Mar 17;119(10):1417-23 - PubMed
  45. J Neurosci. 2020 May 6;40(19):3849-3861 - PubMed
  46. Stroke. 2016 Sep;47(9):2221-8 - PubMed
  47. Stroke. 1996 Oct;27(10):1739-43 - PubMed
  48. Nat Med. 2007 Apr;13(4):463-9 - PubMed
  49. Front Pediatr. 2017 Feb 28;5:23 - PubMed
  50. Curr Biol. 1998 Jul 30-Aug 13;8(16):923-6 - PubMed
  51. Acta Neuropathol Commun. 2019 Jun 10;7(1):94 - PubMed
  52. J Cereb Blood Flow Metab. 2015 Jun;35(6):888-901 - PubMed
  53. J Neurol Sci. 2015 Feb 15;349(1-2):190-5 - PubMed
  54. Brain Res. 1997 Jun 6;759(1):103-11 - PubMed
  55. Int J Biol Macromol. 2012 Oct;51(3):196-200 - PubMed
  56. Neurobiol Dis. 2009 Jul;35(1):82-90 - PubMed

Publication Types

Grant support