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Kasimova AA, Cahill SM, Shpirt AM, et al. The K139 capsular polysaccharide produced by Acinetobacter baumannii MAR17-1041 belongs to a group of related structures including K14, K37 and K116. Int J Biol Macromol. 2021;193:2297-2303doi: 10.1016/j.ijbiomac.2021.11.062.
Kasimova, A. A., Cahill, S. M., Shpirt, A. M., Dudnik, A. G., Shneider, M. M., Popova, A. V., Shelenkov, A. A., Mikhailova, Y. V., Chizhov, A. O., Kenyon, J. J., & Knirel, Y. A. (2021). The K139 capsular polysaccharide produced by Acinetobacter baumannii MAR17-1041 belongs to a group of related structures including K14, K37 and K116. International journal of biological macromolecules, 1932297-2303. https://doi.org/10.1016/j.ijbiomac.2021.11.062
Kasimova, Anastasiya A, et al. "The K139 capsular polysaccharide produced by Acinetobacter baumannii MAR17-1041 belongs to a group of related structures including K14, K37 and K116." International journal of biological macromolecules vol. 193 (2021): 2297-2303. doi: https://doi.org/10.1016/j.ijbiomac.2021.11.062
Kasimova AA, Cahill SM, Shpirt AM, Dudnik AG, Shneider MM, Popova AV, Shelenkov AA, Mikhailova YV, Chizhov AO, Kenyon JJ, Knirel YA. The K139 capsular polysaccharide produced by Acinetobacter baumannii MAR17-1041 belongs to a group of related structures including K14, K37 and K116. Int J Biol Macromol. 2021 Dec 15;193:2297-2303. doi: 10.1016/j.ijbiomac.2021.11.062. Epub 2021 Nov 15. PMID: 34793811.
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Int J Biol Macromol. 2021 Dec 15;193:2297-2303. doi: 10.1016/j.ijbiomac.2021.11.062. Epub 2021 Nov 15.

The K139 capsular polysaccharide produced by Acinetobacter baumannii MAR17-1041 belongs to a group of related structures including K14, K37 and K116.

International journal of biological macromolecules

Anastasiya A Kasimova, Sarah M Cahill, Anna M Shpirt, Aleksandra G Dudnik, Mikhail M Shneider, Anastasiya V Popova, Andrey A Shelenkov, Yuliya V Mikhailova, Alexander O Chizhov, Johanna J Kenyon, Yuriy A Knirel

Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
  2. Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
  3. D.I. Mendeleev University of Chemical Technology of Russia, Moscow, Russia.
  4. M. M. Shemyakin & Y. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, Smolensk, Russia.
  5. State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, Russia.
  6. Central Scientific Research Institute of Epidemiology, Moscow, Russia.
  7. Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia. Electronic address: [email protected].

PMID: 34793811 DOI: 10.1016/j.ijbiomac.2021.11.062

Abstract

Capsular polysaccharide (CPS) is a key target for bacteriophage and vaccine therapies currently being developed for treatment of infections caused by the extensively antibiotic resistant bacterial species, Acinetobacter baumannii. Identification of new CPS structures and the genetics that drive their synthesis underpins tailored treatment strategies. A novel CPS biosynthesis gene cluster, designated KL139, was identified in the whole genome sequence of a multiply antibiotic resistant clinical isolate, A. baumannii MAR-17-1041, recovered in Russia in 2017. CPS material extracted from A. baumannii MAR-17-1041 was studied by sugar analysis and Smith degradation along with one- and two-dimensional

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Acinetobacter baumannii; Capsular polysaccharide; K locus; K139

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