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de Brito JM, de Ameida FM, Arantes-Costa FM, et al. Effects of intrauterine exposure to concentrated ambient particles on allergic sensitization in juvenile mice. Toxicology. 2021;463:152970doi: 10.1016/j.tox.2021.152970.
de Brito, J. M., de Ameida, F. M., Arantes-Costa, F. M., Guimarães, E. T., Morgan, A., Mangone, F. R., Pavanelli, A. C., Nagai, M. A., Vieira, R. P., Macchione, M., & Mauad, T. (2021). Effects of intrauterine exposure to concentrated ambient particles on allergic sensitization in juvenile mice. Toxicology, 463152970. https://doi.org/10.1016/j.tox.2021.152970
de Brito, Jôse Mára, et al. "Effects of intrauterine exposure to concentrated ambient particles on allergic sensitization in juvenile mice." Toxicology vol. 463 (2021): 152970. doi: https://doi.org/10.1016/j.tox.2021.152970
de Brito JM, de Ameida FM, Arantes-Costa FM, Guimarães ET, Morgan A, Mangone FR, Pavanelli AC, Nagai MA, Vieira RP, Macchione M, Mauad T. Effects of intrauterine exposure to concentrated ambient particles on allergic sensitization in juvenile mice. Toxicology. 2021 Nov;463:152970. doi: 10.1016/j.tox.2021.152970. Epub 2021 Oct 01. PMID: 34606951.
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Toxicology. 2021 Nov;463:152970. doi: 10.1016/j.tox.2021.152970. Epub 2021 Oct 01.

Effects of intrauterine exposure to concentrated ambient particles on allergic sensitization in juvenile mice.

Toxicology

Jôse Mára de Brito, Francine Maria de Ameida, Fernanda Magalhães Arantes-Costa, Eliane Tigre Guimarães, Adriana Morgan, Flavia Rotea Mangone, Ana Carolina Pavanelli, Maria Aparecida Nagai, Rodolfo P Vieira, Mariângela Macchione, Thais Mauad

Affiliations

  1. Departamento Patologia, Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address: [email protected].
  2. Departamento de Clinica Médica (LIM 20), Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address: [email protected].
  3. Departamento de Clinica Médica (LIM 20), Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address: [email protected].
  4. Departamento Patologia, Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address: [email protected].
  5. Departamento Patologia, Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address: [email protected].
  6. Laboratory of Molecular Genetics, Center for Translational Research in Oncology, Cancer Institute of the State of São Paulo (ICESP), 01246-000, São Paulo, Brazil. Electronic address: [email protected].
  7. Laboratory of Molecular Genetics, Center for Translational Research in Oncology, Cancer Institute of the State of São Paulo (ICESP), 01246-000, São Paulo, Brazil. Electronic address: [email protected].
  8. Laboratory of Molecular Genetics, Center for Translational Research in Oncology, Cancer Institute of the State of São Paulo (ICESP), 01246-000, São Paulo, Brazil; Discipline of Oncology, Department of Radiology and Oncology, Faculty of Medicine, University of São Paulo, 01246-903, São Paulo, Brazil. Electronic address: [email protected].
  9. Federal University of Sao Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Rua Talim 330, Sao Jose Dos Campos, SP, 12231-280, Brazil; Universidade Brasil, Post-graduation Program in Bioengineering, Rua Carolina Fonseca 235, São Paulo, SP, 08230-030, Brazil. Electronic address: [email protected].
  10. Departamento Patologia, Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address: [email protected].
  11. Departamento Patologia, Faculdade de Medicina da Universidade de São Paulo, Brazil. Electronic address: [email protected].

PMID: 34606951 DOI: 10.1016/j.tox.2021.152970

Abstract

Intrauterine exposure to particulate matter (PM) has been associated with an increased risk of asthma development, which may differ by the age of asthma onset, sex, and pollutant concentration. To investigate the pulmonary effects of in utero exposure to concentrated urban ambient particles (CAPs) in response to house dust mite (HDM) sensitization in juvenile mice. Mice were exposed to CAPs (600 μg/m

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Asthma; House dust mites; Inflammation; Particulate matter; Toxicity

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