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Matsuoka A, Miike T, Miyazaki M, et al. Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study. Trauma Surg Acute Care Open. 2021;6(1):e000827doi: 10.1136/tsaco-2021-000827.
Matsuoka, A., Miike, T., Miyazaki, M., Goto, T., Sasaki, A., Yamazaki, H., Komaki, M., Higuchi, M., Mori, K., Shinada, K., Nakayama, K., Sakurai, R., Asahi, M., Futami, A., Yoshitake, K., Narumi, S., Koba, M., Koami, H., Kawaguchi, A., Murakawa, T. H., Monji, A., & Sakamoto, Y. (2021). Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study. Trauma surgery & acute care open, 6(1), e000827. https://doi.org/10.1136/tsaco-2021-000827
Matsuoka, Ayaka, et al. "Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study." Trauma surgery & acute care open vol. 6,1 (2021): e000827. doi: https://doi.org/10.1136/tsaco-2021-000827
Matsuoka A, Miike T, Miyazaki M, Goto T, Sasaki A, Yamazaki H, Komaki M, Higuchi M, Mori K, Shinada K, Nakayama K, Sakurai R, Asahi M, Futami A, Yoshitake K, Narumi S, Koba M, Koami H, Kawaguchi A, Murakawa TH, Monji A, Sakamoto Y. Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study. Trauma Surg Acute Care Open. 2021 Nov 29;6(1):e000827. doi: 10.1136/tsaco-2021-000827. eCollection 2021. PMID: 34901468; PMCID: PMC8634003.
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Trauma Surg Acute Care Open. 2021 Nov 29;6(1):e000827. doi: 10.1136/tsaco-2021-000827. eCollection 2021.

Development of a delirium predictive model for adult trauma patients in an emergency and critical care center: a retrospective study.

Trauma surgery & acute care open

Ayaka Matsuoka, Toru Miike, Mariko Miyazaki, Taku Goto, Akira Sasaki, Hirotaka Yamazaki, Moe Komaki, Masahiro Higuchi, Kosuke Mori, Kota Shinada, Kento Nakayama, Ryota Sakurai, Miho Asahi, Akiko Futami, Kunimasa Yoshitake, Shougo Narumi, Mayuko Koba, Hiroyuki Koami, Atsushi Kawaguchi, Toru Hirachi Murakawa, Akira Monji, Yuichirou Sakamoto

Affiliations

  1. Emergency and Critical Care Medicine, Saga University Hospital, Saga City, Japan.
  2. Education and Research Center for Community Medicine, Saga University, Saga, Japan.
  3. Psychiatry, Faculty of Medicine, Saga University Hospital, Saga City, Japan.

PMID: 34901468 PMCID: PMC8634003 DOI: 10.1136/tsaco-2021-000827

Abstract

BACKGROUND: Delirium has been shown to prolong the length of intensive care unit stay, hospitalization, and duration of ventilatory control, in addition to increasing the use of sedatives and increasing the medical costs. Although there have been a number of reports referring to risk factors for the development of delirium, no model has been developed to predict delirium in trauma patients at the time of admission. This study aimed to create a scoring system that predicts delirium in trauma patients.

METHODS: In this single-center, retrospective, observational study, trauma patients aged 18 years and older requiring hospitalization more than 48 hours were included and divided into the development and validation cohorts. Univariate analysis was performed in the development cohort to identify factors significantly associated with prediction of delirium. The final scoring system for predicting delirium was developed using multivariate analysis and internal validation was performed.

RESULTS: Of the 308 patients in the development cohort, 91 developed delirium. Clinical Frailty Score, fibrin/fibrinogen degradation products, low body mass index, lactate level, and Glasgow Coma Scale score were independently associated with the development of delirium. We developed a scoring system using these factors and calculated the delirium predictive score, which had an area under the curve of 0.85. In the validation cohort, 46 of 206 patients developed delirium. The area under the curve for the validation cohort was 0.86, and the calibration plot analysis revealed the scoring system was well calibrated in the validation cohort.

DISCUSSION: This scoring system for predicting delirium in trauma patients consists of only five risk factors. Delirium prediction at the time of admission may be useful in clinical practice.

LEVEL OF EVIDENCE: Prognostic and epidemiological, level III.

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: adult; frailty; multiple trauma

Conflict of interest statement

Competing interests: None declared.

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