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Dudoignon B, Tainturier LE, Dodet P, et al. Functional brain imaging using 18F-fluorodeoxyglucose positron emission tomography/computerized tomography in 138 patients with Kleine-Levin syndrome: an early marker?. Brain Commun. 2021;3(2):fcab130doi: 10.1093/braincomms/fcab130.
Dudoignon, B., Tainturier, L. E., Dodet, P., Bera, G., Groos, E., Chaumereuil, C., Maranci, J. B., Kas, A., & Arnulf, I. (2021). Functional brain imaging using 18F-fluorodeoxyglucose positron emission tomography/computerized tomography in 138 patients with Kleine-Levin syndrome: an early marker?. Brain communications, 3(2), fcab130. https://doi.org/10.1093/braincomms/fcab130
Dudoignon, Benjamin, et al. "Functional brain imaging using 18F-fluorodeoxyglucose positron emission tomography/computerized tomography in 138 patients with Kleine-Levin syndrome: an early marker?." Brain communications vol. 3,2 (2021): fcab130. doi: https://doi.org/10.1093/braincomms/fcab130
Dudoignon B, Tainturier LE, Dodet P, Bera G, Groos E, Chaumereuil C, Maranci JB, Kas A, Arnulf I. Functional brain imaging using 18F-fluorodeoxyglucose positron emission tomography/computerized tomography in 138 patients with Kleine-Levin syndrome: an early marker?. Brain Commun. 2021 Jun 17;3(2):fcab130. doi: 10.1093/braincomms/fcab130. eCollection 2021. PMID: 34189461; PMCID: PMC8226192.
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Brain Commun. 2021 Jun 17;3(2):fcab130. doi: 10.1093/braincomms/fcab130. eCollection 2021.

Functional brain imaging using 18F-fluorodeoxyglucose positron emission tomography/computerized tomography in 138 patients with Kleine-Levin syndrome: an early marker?.

Brain communications

Benjamin Dudoignon, Laure-Eugénie Tainturier, Pauline Dodet, Géraldine Bera, Elisabeth Groos, Charlotte Chaumereuil, Jean-Baptiste Maranci, Aurélie Kas, Isabelle Arnulf

Affiliations

  1. Sorbonne University, Paris Brain Institute (ICM), Inserm UMR-S975, CNRS UMR7225, Paris 75013, France.
  2. Sleep Disorders Unit, National Reference Centre for Kleine-Levin Syndrome, Pitié Salpêtrière University Hospital, APHP, Paris 75013, France.
  3. Nuclear Medicine Department, Hôpitaux Universitaires Pitié-Salpêtrière University Hospital, Sorbonne University, AP-HP, Paris 75013, France.
  4. LIB, INSERM U1146, 75013 Paris, France.

PMID: 34189461 PMCID: PMC8226192 DOI: 10.1093/braincomms/fcab130

Abstract

Kleine-Levin syndrome is a rare disorder characterized by relapsing-remitting episodes of severe hypersomnia, cognitive impairment, apathy, derealization and behavioural disturbances. Between episodes, most patients experience normal sleep, mood and behaviour, but they may have some residual abnormalities in brain functional imaging; however, the frequency, localization and significance of abnormal imaging are unknown, as brain functional imaging have been scarce and heterogenous [including scintigraphy 18F-fluorodeoxyglucose positron emission tomography/computerized tomography (FDG-PET/CT) and functional MRI during resting state and cognitive effort] and based on case reports or on group analysis in small groups. Using visual individual analysis of 18F-fluorodeoxyglucose positron emission tomography/computerized tomography at the time of Kleine-Levin syndrome diagnosis, we examined the frequency, localization and clinical determinants of hypo- and hypermetabolism in a cross-sectional study. Among 179 patients with Kleine-Levin syndrome who underwent 18F-fluorodeoxyglucose positron emission tomography/computerized tomography, the visual analysis was restricted to the 138 untreated patients studied during asymptomatic periods. As many as 70% of patients had hypometabolism, mostly affecting the posterior associative cortex and the hippocampus. Hypometabolism was associated with younger age, recent (<3

© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

Keywords: FDG-PET/CT; Kleine–Levin syndrome; adolescence; cognition; functional imaging

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