Display options
Cite
Calò L, Bianchi V, Ferraioli D, et al. Multiparametric Implantable Cardioverter-Defibrillator Algorithm for Heart Failure Risk Stratification and Management: An Analysis in Clinical Practice. Circ Heart Fail. 2021;14(10):e008134doi: 10.1161/CIRCHEARTFAILURE.120.008134.
Calò, L., Bianchi, V., Ferraioli, D., Santini, L., Dello Russo, A., Carriere, C., Santobuono, V. E., Andreoli, C., La Greca, C., Arena, G., Talarico, A., Pisanò, E., Santoro, A., Giammaria, M., Ziacchi, M., Viscusi, M., De Ruvo, E., Campari, M., Valsecchi, S., D'Onofrio, A. (2021). Multiparametric Implantable Cardioverter-Defibrillator Algorithm for Heart Failure Risk Stratification and Management: An Analysis in Clinical Practice. Circulation. Heart failure, 14(10), e008134. https://doi.org/10.1161/CIRCHEARTFAILURE.120.008134
Calò, Leonardo, et al. "Multiparametric Implantable Cardioverter-Defibrillator Algorithm for Heart Failure Risk Stratification and Management: An Analysis in Clinical Practice." Circulation. Heart failure vol. 14,10 (2021): e008134. doi: https://doi.org/10.1161/CIRCHEARTFAILURE.120.008134
Calò L, Bianchi V, Ferraioli D, Santini L, Dello Russo A, Carriere C, Santobuono VE, Andreoli C, La Greca C, Arena G, Talarico A, Pisanò E, Santoro A, Giammaria M, Ziacchi M, Viscusi M, De Ruvo E, Campari M, Valsecchi S, D'Onofrio A. Multiparametric Implantable Cardioverter-Defibrillator Algorithm for Heart Failure Risk Stratification and Management: An Analysis in Clinical Practice. Circ Heart Fail. 2021 Oct;14(10):e008134. doi: 10.1161/CIRCHEARTFAILURE.120.008134. Epub 2021 Jun 30. PMID: 34190592; PMCID: PMC8522625.
Copy Download .nbib Format: NLM
Share it on

Circ Heart Fail. 2021 Oct;14(10):e008134. doi: 10.1161/CIRCHEARTFAILURE.120.008134. Epub 2021 Jun 30.

Multiparametric Implantable Cardioverter-Defibrillator Algorithm for Heart Failure Risk Stratification and Management: An Analysis in Clinical Practice.

Circulation. Heart failure

Leonardo Calò, Valter Bianchi, Donatella Ferraioli, Luca Santini, Antonio Dello Russo, Cosimo Carriere, Vincenzo Ezio Santobuono, Chiara Andreoli, Carmelo La Greca, Giuseppe Arena, Antonello Talarico, Ennio Pisanò, Amato Santoro, Massimo Giammaria, Matteo Ziacchi, Miguel Viscusi, Ermenegildo De Ruvo, Monica Campari, Sergio Valsecchi, Antonio D'Onofrio,

Affiliations

  1. Cardiology Department, Policlinico Casilino, Rome, Italy (L.C., E.D.R.).
  2. Unità Operativa di Elettrofisiologia, Studio e Terapia delle Aritmie," Monaldi Hospital, Naples, Italy (V.B., A.D.).
  3. Cardiology Department, OO.RR. San Giovanni di Dio Ruggi d'Aragona, Salerno, Italy (D.F.).
  4. Cardiology Department, "Giovan Battista Grassi" Hospital, Rome, Italy (L.S.).
  5. Clinica di Cardiologia e Aritmologia, Università Politecnica delle Marche, "Ospedali Riuniti," Ancona, Italy (A.D.R.).
  6. Cardiology Department, Azienda Ospedaliera Universitaria Ospedali Riuniti di Trieste - Cattinara, Trieste, Italy (C.C.).
  7. Cardiology Department, University of Bari, Policlinico di Bari, Italy (V.E.S.).
  8. Cardiology Department, S. Giovanni Battista Hospital, Foligno, Italy (C.A.).
  9. Cardiology Department, Fondazione Poliambulanza, Brescia, Italy (C.L.G.).
  10. Cardiology Department, Ospedale Civile Apuane, Massa, Italy (G.A.).
  11. Cardiology Department, SS. Annunziata Hospital, Cosenza, Italy (A.T.).
  12. Cardiology Department, Vito Fazzi Hospital, Lecce, Italy (E.P.).
  13. Cardiology Department, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena, Italy (A.S.).
  14. Division of Cardiology, Maria Vittoria Hospital, Turin, Italy (M.G.).
  15. Institute of Cardiology, University of Bologna, S.Orsola-Malpighi University Hospital, Italy (M.Z.).
  16. Cardiology Department, S. Anna e S. Sebastiano Hospital, Caserta, Italy (M.V.).
  17. Rhythm Management Department, Boston Scientific Italia, Milan, Italy (M.C., S.V.).

PMID: 34190592 PMCID: PMC8522625 DOI: 10.1161/CIRCHEARTFAILURE.120.008134

Abstract

BACKGROUND: The HeartLogic algorithm combines multiple implantable cardioverter-defibrillator sensors to identify patients at risk of heart failure (HF) events. We sought to evaluate the risk stratification ability of this algorithm in clinical practice. We also analyzed the alert management strategies adopted in the study group and their association with the occurrence of HF events.

METHODS: The HeartLogic feature was activated in 366 implantable cardioverter-defibrillator and cardiac resynchronization therapy implantable cardioverter-defibrillator patients at 22 centers. The median follow-up was 11 months [25th-75th percentile: 6-16]. The HeartLogic algorithm calculates a daily HF index and identifies periods IN alert state on the basis of a configurable threshold.

RESULTS: The HeartLogic index crossed the threshold value 273 times (0.76 alerts/patient-year) in 150 patients. The time IN alert state was 11% of the total observation period. Patients experienced 36 HF hospitalizations, and 8 patients died of HF during the observation period. Thirty-five events were associated with the IN alert state (0.92 events/patient-year versus 0.03 events/patient-year in the OUT of alert state). The hazard ratio in the IN/OUT of alert state comparison was (hazard ratio, 24.53 [95% CI, 8.55-70.38],

CONCLUSIONS: This multiparametric algorithm identifies patients during periods of significantly increased risk of HF events. The rate of HF events seemed lower when clinical actions were undertaken in response to alerts. Extra in-office visits did not seem to be required to effectively manage HeartLogic alerts. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02275637.

Keywords: algorithm; defibrillator, implantable; heart failure; hospitalization; risk

References

  1. Circ Heart Fail. 2018 Jul;11(7):e004669 - PubMed
  2. J Cardiovasc Med (Hagerstown). 2020 Mar;21(3):171-181 - PubMed
  3. Eur Heart J. 2017 Jun 7;38(22):1749-1755 - PubMed
  4. Eur Heart J. 2011 Sep;32(18):2266-73 - PubMed
  5. J Card Fail. 2020 Feb;26(2):151-159 - PubMed
  6. Circulation. 2012 Jun 19;125(24):2985-92 - PubMed
  7. Lancet. 2011 Feb 19;377(9766):658-66 - PubMed
  8. J Am Coll Cardiol. 2010 Apr 27;55(17):1803-10 - PubMed
  9. Europace. 2018 May 1;20(5):e69-e77 - PubMed
  10. Eur Heart J. 2013 Aug;34(31):2472-80 - PubMed
  11. Eur Heart J. 2016 Jul 14;37(27):2129-2200 - PubMed
  12. Eur J Heart Fail. 2017 Mar;19(3):416-425 - PubMed
  13. Clin Cardiol. 2020 Jul;43(7):691-697 - PubMed
  14. J Interv Card Electrophysiol. 2020 Jun;58(1):95-101 - PubMed
  15. ESC Heart Fail. 2019 Apr;6(2):308-318 - PubMed
  16. Eur Heart J. 2017 Aug 7;38(30):2352-2360 - PubMed
  17. Circulation. 2011 Oct 18;124(16):1719-26 - PubMed
  18. Heart Rhythm. 2015 Jul;12(7):e69-100 - PubMed
  19. BMC Cardiovasc Disord. 2018 Feb 7;18(1):25 - PubMed
  20. J Am Coll Cardiol. 2011 Mar 8;57(10):1181-9 - PubMed
  21. JACC Heart Fail. 2016 May;4(5):333-44 - PubMed
  22. Lancet. 2014 Aug 16;384(9943):583-590 - PubMed
  23. JACC Heart Fail. 2017 Mar;5(3):216-225 - PubMed

Publication Types