Commun Biol. 2021 Dec 14;4(1):1395. doi: 10.1038/s42003-021-02931-3.

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates.

Communications biology

Davide Simone, Frank Penkava, Anna Ridley, Stephen Sansom, M Hussein Al-Mossawi, Paul Bowness

PMID: 34907325 DOI: 10.1038/s42003-021-02931-3

Abstract

Regulatory T cells (Tregs) play an important role in controlling inflammation and limiting autoimmunity, but their phenotypes at inflammatory sites in human disease are poorly understood. We here analyze the single-cell transcriptome of >16,000 Tregs obtained from peripheral blood and synovial fluid of two patients with HLA-B27+ ankylosing spondylitis and three patients with psoriatic arthritis, closely related forms of inflammatory spondyloarthritis. We identify multiple Treg clusters with distinct transcriptomic profiles, including, among others, a regulatory CD8

© 2021. The Author(s).

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