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Cui L, Saeed Y, Li H, et al. Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies. Regen Med. 2021;17(1):37-53doi: 10.2217/rme-2021-0069.
Cui, L., Saeed, Y., Li, H., & Yang, J. (2022). Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies. Regenerative medicine, 17(1), 37-53. https://doi.org/10.2217/rme-2021-0069
Cui, Lianxu, et al. "Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies." Regenerative medicine vol. 17,1 (2022): 37-53. doi: https://doi.org/10.2217/rme-2021-0069
Cui L, Saeed Y, Li H, Yang J. Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies. Regen Med. 2022 Jan;17(1):37-53. doi: 10.2217/rme-2021-0069. Epub 2021 Dec 15. PMID: 34905963.
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Regen Med. 2022 Jan;17(1):37-53. doi: 10.2217/rme-2021-0069. Epub 2021 Dec 15.

Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies.

Regenerative medicine

Lianxu Cui, Yasmeen Saeed, Haomin Li, Jingli Yang

Affiliations

  1. Department of Neurosurgery, The First People's Hospital of Foshan, 81 North Lingnan Road, Foshan, Guangdong, 528300, PR China.
  2. Guangdong VitaLife Biotechnology Co., LTD, 61 Xiannan Road, Nanhai District, Foshan, Guangdong, 528200, PR China.
  3. School of medicine, Foshan University, 18 Jiangwan Road, Foshan, Guangdong, 528000, PR China.

PMID: 34905963 DOI: 10.2217/rme-2021-0069

Abstract

Traumatic brain injury (TBI) is a serious health concern, yet there is a lack of standardized treatment to combat its long-lasting effects. The objective of the present study was to provide an overview of the limitation of conventional stem-cell therapy in the treatment of TBI and to discuss the application of novel acellular therapies and their advanced strategies to enhance the efficacy of stem cells derived therapies in the light of published study data. Moreover, we also discussed the factor to optimize the therapeutic efficiency of stem cell-derived acellular therapy by overcoming the challenges for its clinical translation. Hence, we concluded that acellular therapy possesses the potential to bring a breakthrough in the field of regenerative medicine to treat TBI.

Keywords: acellular therapy; cell secretome; exosomes; paracrine effects; regenerative medicine; traumatic brain injury

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