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Virology. 2021 Jul;559:100-110. doi: 10.1016/j.virol.2021.03.019. Epub 2021 Apr 09.

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8.

Virology

Blake Schouest, Brandon J Beddingfield, Margaret H Gilbert, Rudolf P Bohm, Faith Schiro, Pyone P Aye, Antonito T Panganiban, Diogo M Magnani, Nicholas J Maness

Affiliations

  1. Tulane National Primate Research Center, Tulane University, Covington, LA, USA; Biomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA.
  2. Tulane National Primate Research Center, Tulane University, Covington, LA, USA.
  3. Tulane National Primate Research Center, Tulane University, Covington, LA, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  4. Department of Medicine, University of Massachusetts, Boston, MA, USA.
  5. Tulane National Primate Research Center, Tulane University, Covington, LA, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address: [email protected].

PMID: 33865073 PMCID: PMC8212702 DOI: 10.1016/j.virol.2021.03.019

Abstract

While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were depleted of CD8

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Keywords: CD8(+) T cells; Macaques; Nonhuman primates; Pregnancy; Zika virus

References

  1. J Immunol. 2005 Jul 15;175(2):1184-91 - PubMed
  2. Cell Host Microbe. 2017 Jan 11;21(1):35-46 - PubMed
  3. PLoS Pathog. 2017 Apr 5;13(4):e1006317 - PubMed
  4. PLoS Negl Trop Dis. 2016 Jun 24;10(6):e0004816 - PubMed
  5. J Virol. 2005 Sep;79(17):11457-66 - PubMed
  6. Nat Commun. 2016 Jun 28;7:12204 - PubMed
  7. PLoS Pathog. 2017 Feb 23;13(2):e1006184 - PubMed
  8. Trans R Soc Trop Med Hyg. 1952 Sep;46(5):509-20 - PubMed
  9. PLoS Pathog. 2017 May 25;13(5):e1006378 - PubMed
  10. Cell Host Microbe. 2016 Jun 8;19(6):882-90 - PubMed
  11. Lancet. 2016 Apr 2;387(10026):1482 - PubMed
  12. J R Coll Physicians Edinb. 2016 Jun;46(2):103-105 - PubMed
  13. Front Immunol. 2019 Sep 04;10:2125 - PubMed
  14. Nat Commun. 2018 Apr 24;9(1):1624 - PubMed
  15. Clin Obstet Gynecol. 2012 Jun;55(2):474-86 - PubMed
  16. J Infect Dis. 2019 Sep 13;220(8):1377-1387 - PubMed
  17. Mem Inst Oswaldo Cruz. 2015 Jun;110(4):569-72 - PubMed
  18. Front Immunol. 2017 Nov 10;8:1521 - PubMed
  19. J Virol. 2004 Aug;78(15):8312-21 - PubMed
  20. Genome Biol. 2014;15(12):550 - PubMed
  21. Virus Res. 2018 Aug 2;254:34-40 - PubMed
  22. J Virol. 2018 Mar 14;92(7): - PubMed
  23. JAMA Neurol. 2016 Dec 1;73(12):1407-1416 - PubMed
  24. Nat Med. 2016 Dec;22(12):1448-1455 - PubMed
  25. Nat Commun. 2018 Aug 2;9(1):3042 - PubMed
  26. Lancet. 2016 Jun 25;387(10038):2599 - PubMed
  27. Nucleic Acids Res. 2015 Apr 20;43(7):e47 - PubMed
  28. Immunity. 2013 Aug 22;39(2):211-27 - PubMed
  29. J Infect Dis. 2011 May 1;203(9):1301-8 - PubMed
  30. J Gen Virol. 2006 Dec;87(Pt 12):3599-3609 - PubMed
  31. J Virol. 2003 Dec;77(24):13323-34 - PubMed
  32. Obstet Gynecol. 2012 Mar;119(3):631-9 - PubMed
  33. PLoS One. 2013 Nov 8;8(11): - PubMed
  34. CMAJ. 2016 Apr 19;188(7):E118-E119 - PubMed
  35. Nat Rev Immunol. 2017 Aug;17(8):469-482 - PubMed
  36. J Immunol. 2009 Apr 15;182(8):4865-73 - PubMed
  37. JAMA Pediatr. 2017 Mar 1;171(3):288-295 - PubMed
  38. J Virol. 2017 Mar 29;91(8): - PubMed
  39. J Immunol. 2009 Dec 15;183(12):7919-30 - PubMed
  40. PLoS Negl Trop Dis. 2017 Dec 21;11(12):e0006000 - PubMed
  41. N Engl J Med. 2014 Jun 5;370(23):2211-8 - PubMed
  42. J Immunol. 2005 Apr 1;174(7):4198-202 - PubMed
  43. J Virol. 2017 Oct 27;91(22): - PubMed
  44. J Immunol. 2018 Dec 15;201(12):3487-3491 - PubMed
  45. PLoS Curr. 2016 Nov 15;8: - PubMed
  46. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 - PubMed
  47. Nat Commun. 2018 Aug 22;9(1):3371 - PubMed
  48. Arq Neuropsiquiatr. 2016 Mar;74(3):253-5 - PubMed
  49. PLoS One. 2017 Jan 31;12(1):e0171148 - PubMed
  50. Nat Commun. 2019 Dec 12;10(1):5677 - PubMed
  51. J Immunol. 2015 Feb 1;194(3):1141-53 - PubMed
  52. PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005168 - PubMed
  53. Nat Microbiol. 2017 Nov;2(11):1558-1570 - PubMed
  54. Bioinformatics. 2013 Jan 1;29(1):15-21 - PubMed
  55. Sci Rep. 2019 Sep 5;9(1):12802 - PubMed
  56. Immunology. 2017 Feb;150(2):146-154 - PubMed
  57. Immunology. 2009 Sep;128(1 Suppl):e718-27 - PubMed
  58. BMC Bioinformatics. 2013 Jan 16;14:7 - PubMed
  59. Nat Med. 2011 Aug 21;17(9):1128-31 - PubMed
  60. Cell Rep. 2017 Jan 10;18(2):324-333 - PubMed
  61. J Virol. 2016 Apr 14;90(9):4771-4779 - PubMed
  62. Front Microbiol. 2016 Dec 19;7:2028 - PubMed
  63. J Exp Med. 2017 Aug 7;214(8):2303-2313 - PubMed
  64. PLoS One. 2015 Sep 18;10(9):e0138729 - PubMed
  65. J Virol. 2006 Jan;80(1):119-29 - PubMed
  66. JCI Insight. 2017 Dec 21;2(24): - PubMed
  67. JAMA. 2014 May 7;311(17):1760-9 - PubMed
  68. Nat Microbiol. 2017 Nov;2(11):1462-1470 - PubMed
  69. Mol Biosyst. 2016 Feb;12(2):477-9 - PubMed
  70. Nat Rev Microbiol. 2018 Oct;16(10):594-600 - PubMed
  71. Annu Rev Immunol. 2018 Apr 26;36:279-308 - PubMed
  72. J Virol. 2020 Feb 14;94(5): - PubMed
  73. Emerg Infect Dis. 2016 Jul;22(7):1185-92 - PubMed
  74. Cell. 2016 May 19;165(5):1081-1091 - PubMed
  75. J Virol. 2017 Nov 30;91(24): - PubMed

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