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Paloschi V, Sabater-Lleal M, Middelkamp H, et al. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovasc Res. 2021;117(14):2742-2754doi: 10.1093/cvr/cvab088.
Paloschi, V., Sabater-Lleal, M., Middelkamp, H., Vivas, A., Johansson, S., van der Meer, A., Tenje, M., & Maegdefessel, L. (2021). Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovascular research, 117(14), 2742-2754. https://doi.org/10.1093/cvr/cvab088
Paloschi, Valentina, et al. "Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases." Cardiovascular research vol. 117,14 (2021): 2742-2754. doi: https://doi.org/10.1093/cvr/cvab088
Paloschi V, Sabater-Lleal M, Middelkamp H, Vivas A, Johansson S, van der Meer A, Tenje M, Maegdefessel L. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovasc Res. 2021 Dec 17;117(14):2742-2754. doi: 10.1093/cvr/cvab088. PMID: 33729461.
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Cardiovasc Res. 2021 Dec 17;117(14):2742-2754. doi: 10.1093/cvr/cvab088.

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases.

Cardiovascular research

Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, Aisen Vivas, Sofia Johansson, Andries van der Meer, Maria Tenje, Lars Maegdefessel

Affiliations

  1. Department for Vascular and Endovascular Surgery, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany.
  2. German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Berlin, Germany.
  3. Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Genomics of Complex Diseases Group, Barcelona, Spain.
  4. Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  5. BIOS/Lab on a Chip, University of Twente, Enschede, The Netherlands.
  6. Applied Stem Cell Technologies, University of Twente, Enschede, The Netherlands.
  7. Department of Materials Science and Engineering, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  8. Molecular Vascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

PMID: 33729461 DOI: 10.1093/cvr/cvab088

Abstract

The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture experiments by allowing a better mimicry of human physiology and pathophysiology that has consequently led researchers to gain more meaningful insights into disease mechanisms. Several models of hearts-on-chips and vessels-on-chips have been demonstrated to recapitulate fundamental aspects of the human cardiovascular system in the recent past. These 2D and 3D systems include synchronized beating cardiomyocytes in hearts-on-chips and vessels-on-chips with layer-based structures and the inclusion of physiological and pathological shear stress conditions. The opportunities to discover novel targets and to perform drug testing with chip-based platforms have substantially enhanced, thanks to the utilization of patient-derived cells and precise control of their microenvironment. These organ models will provide an important asset for future approaches to personalized cardiovascular medicine and improved patient care. However, certain technical and biological challenges remain, making the global utilization of OoCs to tackle unanswered questions in cardiovascular science still rather challenging. This review article aims to introduce and summarize published work on hearts- and vessels-on chips but also to provide an outlook and perspective on how these advanced in vitro systems can be used to tailor disease models with patient-specific characteristics.

© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

Keywords: Cardiovascular; Cell culture; Heart; Organs-on-chips; Personalized medicine

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Grant support