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Mennecke AB, Nagel AM, Huhn K, et al. Longitudinal Sodium MRI of Multiple Sclerosis Lesions: Is there Added Value of Sodium Inversion Recovery MRI. J Magn Reson Imaging. 2021;55(1):140-151doi: 10.1002/jmri.27832.
Mennecke, A. B., Nagel, A. M., Huhn, K., Linker, R. A., Schmidt, M., Rothhammer, V., Wilferth, T., Linz, P., Wegmann, J., Eisenhut, F., Engelhorn, T., & Doerfler, A. (2022). Longitudinal Sodium MRI of Multiple Sclerosis Lesions: Is there Added Value of Sodium Inversion Recovery MRI. Journal of magnetic resonance imaging : JMRI, 55(1), 140-151. https://doi.org/10.1002/jmri.27832
Mennecke, Angelika B, et al. "Longitudinal Sodium MRI of Multiple Sclerosis Lesions: Is there Added Value of Sodium Inversion Recovery MRI." Journal of magnetic resonance imaging : JMRI vol. 55,1 (2022): 140-151. doi: https://doi.org/10.1002/jmri.27832
Mennecke AB, Nagel AM, Huhn K, Linker RA, Schmidt M, Rothhammer V, Wilferth T, Linz P, Wegmann J, Eisenhut F, Engelhorn T, Doerfler A. Longitudinal Sodium MRI of Multiple Sclerosis Lesions: Is there Added Value of Sodium Inversion Recovery MRI. J Magn Reson Imaging. 2022 Jan;55(1):140-151. doi: 10.1002/jmri.27832. Epub 2021 Jul 14. PMID: 34259373.
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J Magn Reson Imaging. 2022 Jan;55(1):140-151. doi: 10.1002/jmri.27832. Epub 2021 Jul 14.

Longitudinal Sodium MRI of Multiple Sclerosis Lesions: Is there Added Value of Sodium Inversion Recovery MRI.

Journal of magnetic resonance imaging : JMRI

Angelika B Mennecke, Armin M Nagel, Konstantin Huhn, Ralf A Linker, Manuel Schmidt, Veit Rothhammer, Tobias Wilferth, Peter Linz, Julius Wegmann, Felix Eisenhut, Tobias Engelhorn, Arnd Doerfler

Affiliations

  1. Department of Neuroradiology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
  2. Institute of Radiology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
  3. Division of Medical Physics in Radiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
  4. Department of Neurology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
  5. Department of Neurology, University Clinic Regensburg, Germany.

PMID: 34259373 DOI: 10.1002/jmri.27832

Abstract

BACKGROUND: Sodium enhancement has been demonstrated in multiple sclerosis (MS) lesions.

PURPOSE: To investigate sodium MRI with and without an inversion recovery pulse in acute MS lesions in an MS relapse and during recovery.

STUDY TYPE: Prospective.

SUBJECTS: Twenty-nine relapsing-remitting MS patients with an acute relapse were included.

FIELD STRENGTH/SEQUENCE: A 3D density-adapted radial sodium sequence at 3 T using a dual-tuned (

ASSESSMENT: Full-brain images of the tissue sodium concentration (TSC1, n = 29) and a sodium inversion recovery sequence (SIR1, n = 20) at the beginning of the anti-inflammatory therapy and on medium-term follow-up visits (days 27-99, n = 12 [TSC], n = 5 [SIR]) were measured. Regions of interest (RoIs) with contrast enhancement (T

RESULTS: At the first measurement, all lesion types showed increased nTSC, while nSIR was decreased in the FL + T

DATA CONCLUSION: At time point 1, nTSC is increased, while nSIR is unchanged or decreased in the lesions. The mean sodium IR signal at baseline correlates with recovery or progression of an acute lesion.

EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 4.

© 2021 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC. on behalf of International Society for Magnetic Resonance in Medicine.

Keywords: MRI; inversion recovery; multiple sclerosis; sodium; therapy; white matter

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