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Serruys PW, Hara H, Garg S, et al. Coronary Computed Tomographic Angiography for Complete Assessment of Coronary Artery Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021;78(7):713-736doi: 10.1016/j.jacc.2021.06.019.
Serruys, P. W., Hara, H., Garg, S., Kawashima, H., Nørgaard, B. L., Dweck, M. R., Bax, J. J., Knuuti, J., Nieman, K., Leipsic, J. A., Mushtaq, S., Andreini, D., & Onuma, Y. (2021). Coronary Computed Tomographic Angiography for Complete Assessment of Coronary Artery Disease: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 78(7), 713-736. https://doi.org/10.1016/j.jacc.2021.06.019
Serruys, Patrick W, et al. "Coronary Computed Tomographic Angiography for Complete Assessment of Coronary Artery Disease: JACC State-of-the-Art Review." Journal of the American College of Cardiology vol. 78,7 (2021): 713-736. doi: https://doi.org/10.1016/j.jacc.2021.06.019
Serruys PW, Hara H, Garg S, Kawashima H, Nørgaard BL, Dweck MR, Bax JJ, Knuuti J, Nieman K, Leipsic JA, Mushtaq S, Andreini D, Onuma Y. Coronary Computed Tomographic Angiography for Complete Assessment of Coronary Artery Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Aug 17;78(7):713-736. doi: 10.1016/j.jacc.2021.06.019. PMID: 34384554.
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J Am Coll Cardiol. 2021 Aug 17;78(7):713-736. doi: 10.1016/j.jacc.2021.06.019.

Coronary Computed Tomographic Angiography for Complete Assessment of Coronary Artery Disease: JACC State-of-the-Art Review.

Journal of the American College of Cardiology

Patrick W Serruys, Hironori Hara, Scot Garg, Hideyuki Kawashima, Bjarne L Nørgaard, Marc R Dweck, Jeroen J Bax, Juhani Knuuti, Koen Nieman, Jonathon A Leipsic, Saima Mushtaq, Daniele Andreini, Yoshinobu Onuma

Affiliations

  1. Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland; NHLI, Imperial College London, London, United Kingdom. Electronic address: [email protected].
  2. Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland; Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: https://twitter.com/hara_hironori.
  3. Department of Cardiology, Royal Blackburn Hospital, Blackburn, United Kingdom.
  4. Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland; Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  5. Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  6. Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
  7. Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
  8. Heart Center, Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  9. Department of Radiology and Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
  10. Department of Medicine and Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
  11. Centro Cardiologico Monzino, IRCCS, Milan, Italy.
  12. Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.
  13. Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland.

PMID: 34384554 DOI: 10.1016/j.jacc.2021.06.019

Abstract

Coronary computed tomography angiography (CTA) has shown great technological improvements over the last 2 decades. High accuracy of CTA in detecting significant coronary stenosis has promoted CTA as a substitute for conventional invasive coronary angiography in patients with suspected coronary artery disease. In patients with coronary stenosis, CTA-derived physiological assessment is surrogate for intracoronary pressure and velocity wires, and renders possible decision-making about revascularization solely based on computed tomography. Computed tomography coronary anatomy with functionality assessment could potentially become a first line in diagnosis. Noninvasive imaging assessment of plaque burden and morphology is becoming a valuable substitute for intravascular imaging. Recently, wall shear stress and perivascular inflammation have been introduced. These assessments could support risk management for both primary and secondary cardiovascular prevention. Anatomy, functionality, and plaque composition by CTA tend to replace invasive assessment. Complete CTA assessment could provide a 1-stop-shop for diagnosis, risk management, and decision-making on treatment.

Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Keywords: coronary computed tomography angiography; coronary physiology; coronary plaque

Conflict of interest statement

Funding Support and Author Disclosures Dr Serruys has received personal fees from Biosensors, Micel Technologies, Sinomedical Sciences Technology, Philips/Volcano, Xeltis, and HeartFlow, outside of th

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