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Cancers (Basel). 2021 Apr 30;13(9). doi: 10.3390/cancers13092171.

[No title available]

Cancers

Xuanmao Jiao, Lifeng Tian, Zhao Zhang, Joanna Balcerek, Andrew V Kossenkov, Mathew C Casimiro, Chenguang Wang, Yichuan Liu, Adam Ertel, Raymond E Soccio, Eric R Chen, Qin Liu, Anthony W Ashton, Wei Tong, Richard G Pestell

Affiliations

  1. Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Wynnewood, PA 19096, USA.
  2. Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  3. Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.
  4. Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA 19107, USA.
  5. Department of Science and Mathematics, Abraham Baldwin Agricultural College, Tifton, GA 31794, USA.
  6. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19146, USA.
  7. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  8. Lankenau Institute for Medical Research, Wynnewood, PA 19069, USA.

PMID: 33946495 PMCID: PMC8125290 DOI: 10.3390/cancers13092171

Abstract

HER2, which is associated with clinically aggressive disease, is overexpressed in 15-20% of breast cancers (BC). The host immune system participates in the therapeutic response of HER2

Keywords: breast cancer; lipogenesis; peroxisome proliferator-activated receptor gamma (PPARĪ³), nuclear receptor

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