Display options
Cite
Carraro RS, Nogueira GA, Sidarta-Oliveira D, et al. Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and Attenuates Obesity-Associated Anxiety/Depression-like Behavior. J Neurosci. 2021;41(48):10004-10022doi: 10.1523/JNEUROSCI.0222-21.2021.
Carraro, R. S., Nogueira, G. A., Sidarta-Oliveira, D., Gaspar, R. S., Dragano, N. R., Morari, J., Bobbo, V. C. D., Araujo, E. P., Mendes, N. F., Zanesco, A. M., Tobar, N., Ramos, C. D., Toscaro, J. M., Bajgelman, M. C., & Velloso, L. A. (2021). Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and Attenuates Obesity-Associated Anxiety/Depression-like Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(48), 10004-10022. https://doi.org/10.1523/JNEUROSCI.0222-21.2021
Carraro, Rodrigo S, et al. "Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and Attenuates Obesity-Associated Anxiety/Depression-like Behavior." The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 41,48 (2021): 10004-10022. doi: https://doi.org/10.1523/JNEUROSCI.0222-21.2021
Carraro RS, Nogueira GA, Sidarta-Oliveira D, Gaspar RS, Dragano NR, Morari J, Bobbo VCD, Araujo EP, Mendes NF, Zanesco AM, Tobar N, Ramos CD, Toscaro JM, Bajgelman MC, Velloso LA. Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and Attenuates Obesity-Associated Anxiety/Depression-like Behavior. J Neurosci. 2021 Dec 01;41(48):10004-10022. doi: 10.1523/JNEUROSCI.0222-21.2021. Epub 2021 Oct 21. PMID: 34675088; PMCID: PMC8638695.
Copy Download .nbib Format: NLM
Share it on

J Neurosci. 2021 Dec 01;41(48):10004-10022. doi: 10.1523/JNEUROSCI.0222-21.2021. Epub 2021 Oct 21.

Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and Attenuates Obesity-Associated Anxiety/Depression-like Behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Rodrigo S Carraro, Guilherme A Nogueira, Davi Sidarta-Oliveira, Rodrigo S Gaspar, Nathalia R Dragano, Joseane Morari, Vanessa C D Bobbo, Eliana P Araujo, Natalia F Mendes, Ariane M Zanesco, Natalia Tobar, Celso D Ramos, Jéssica M Toscaro, Marcio C Bajgelman, Licio A Velloso

Affiliations

  1. Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
  2. Nuclear Medicine Service, Department of Radiology, Hospital of Clinics, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil.
  3. Brazilian Center for Research in Energy and Materials, Brazilian Biosciences National Laboratory, Campinas, 13083-970, Sao Paulo, Brazil.
  4. Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 13083-970, Sao Paulo, Brazil [email protected].
  5. National Institute of Science and Technology, Neuroimmunomodulation. Fiocruz, 21040-900, Rio de Janeiro, Brazil.

PMID: 34675088 PMCID: PMC8638695 DOI: 10.1523/JNEUROSCI.0222-21.2021

Abstract

Nescient helix-loop-helix 2 (NHLH2) is a hypothalamic transcription factor that controls the expression of prohormone convertase 1/3, therefore having an impact on the processing of proopiomelanocortin and thus on energy homeostasis. Studies have shown that KO of

Copyright © 2021 the authors.

Keywords: energy expenditure; food intake; insulin; leptin

References

  1. JAMA Pediatr. 2019 Nov 1;173(11):e192841 - PubMed
  2. Mol Endocrinol. 2008 Jun;22(6):1438-48 - PubMed
  3. Gene. 2013 Jan 1;512(1):134-42 - PubMed
  4. PLoS One. 2009;4(4):e5045 - PubMed
  5. Genome Res. 2002 Jun;12(6):996-1006 - PubMed
  6. J Neuroendocrinol. 2007 Jul;19(7):499-510 - PubMed
  7. Trends Mol Med. 2019 Feb;25(2):136-148 - PubMed
  8. Nature. 2020 Aug;584(7819):120-124 - PubMed
  9. Nat Rev Endocrinol. 2016 Dec;12(12):723-733 - PubMed
  10. J Neurosci. 2013 Jun 19;33(25):10459-70 - PubMed
  11. Obesity (Silver Spring). 2008 Dec;16(12):2610-5 - PubMed
  12. Mol Metab. 2020 Jun;36:100963 - PubMed
  13. Int J Obes (Lond). 2010 Mar;34(3):407-19 - PubMed
  14. EMBO J. 2004 Oct 27;23(21):4353-64 - PubMed
  15. Cell Growth Differ. 1992 Mar;3(3):143-8 - PubMed
  16. J Neurosci. 2020 Jul 1;40(27):5300-5313 - PubMed
  17. Psychol Bull. 1976 May;83(3):482-504 - PubMed
  18. Folia Microbiol (Praha). 2010 Jul;55(4):373-5 - PubMed
  19. Biochem Biophys Res Commun. 2020 Feb 26;523(1):1-5 - PubMed
  20. Cell. 2012 Sep 14;150(6):1287-99 - PubMed
  21. Pharmacol Biochem Behav. 1984 Sep;21(3):463-6 - PubMed
  22. Br J Nutr. 2010 Sep;104(6):919-29 - PubMed
  23. EMBO Mol Med. 2015 Jan 23;7(2):190-210 - PubMed
  24. Biochem Biophys Res Commun. 2006 Oct 6;348(4):1411-8 - PubMed
  25. PLoS One. 2011 Jan 05;6(1):e15961 - PubMed
  26. J Clin Invest. 2012 Nov;122(11):4203-12 - PubMed
  27. Genome Biol. 2019 Dec 23;20(1):296 - PubMed
  28. Int J Oral Maxillofac Implants. 1991 Summer;6(2):195-201 - PubMed
  29. Am J Hum Genet. 2007 Apr;80(4):779-91 - PubMed
  30. J Neurosci Methods. 1985 Aug;14(3):149-67 - PubMed
  31. Mol Cell Endocrinol. 2014 Mar 25;384(1-2):134-42 - PubMed
  32. Nat Methods. 2017 Nov;14(11):1083-1086 - PubMed
  33. Mol Endocrinol. 2006 Sep;20(9):2093-108 - PubMed
  34. Nat Commun. 2018 Dec 10;9(1):5272 - PubMed
  35. Cell. 1997 Jan 10;88(1):131-41 - PubMed
  36. J Clin Invest. 2017 Jan 3;127(1):293-305 - PubMed
  37. Nat Biotechnol. 2018 Jun;36(5):411-420 - PubMed
  38. Nat Biotechnol. 2018 Dec 03;: - PubMed
  39. Nat Neurosci. 2017 Mar;20(3):484-496 - PubMed
  40. Endocrinology. 2004 Apr;145(4):1503-13 - PubMed
  41. Neuroendocrinology. 2020;110(1-2):92-104 - PubMed
  42. Nat Protoc. 2020 Jul;15(7):2247-2276 - PubMed
  43. Elife. 2015 Sep 02;4: - PubMed
  44. Curr Diab Rep. 2020 May 26;20(7):29 - PubMed
  45. Nat Genet. 1997 Apr;15(4):397-401 - PubMed
  46. J Clin Endocrinol Metab. 1999 Apr;84(4):1483-6 - PubMed
  47. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8492-6 - PubMed
  48. PLoS One. 2010 Aug 23;5(8):e12324 - PubMed
  49. J Neurochem. 2007 Sep;102(6):2061-2072 - PubMed
  50. Sci Rep. 2016 Jul 04;6:29290 - PubMed
  51. Mol Endocrinol. 2007 Dec;21(12):3013-27 - PubMed
  52. Am J Physiol. 1996 Nov;271(5 Pt 2):R1380-7 - PubMed
  53. Nat Commun. 2019 Aug 16;10(1):3696 - PubMed
  54. Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3103-9 - PubMed
  55. Nat Genet. 1998 Jun;19(2):155-7 - PubMed
  56. Nature. 2007 Jun 28;447(7148):1142 - PubMed
  57. Physiol Behav. 2002 Nov;77(2-3):387-402 - PubMed
  58. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):39-47 - PubMed
  59. FEBS Lett. 2017 Sep;591(17):2593-2606 - PubMed
  60. Transl Psychiatry. 2019 Aug 27;9(1):207 - PubMed
  61. Nat Commun. 2017 May 10;8:15143 - PubMed
  62. Exerc Sport Sci Rev. 2008 Oct;36(4):187-92 - PubMed
  63. ILAR J. 2002;43(4):244-58 - PubMed
  64. Cell. 2011 Dec 23;147(7):1459-72 - PubMed

Publication Types