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Cai C, Bi D, Bick G, et al. Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis. FEBS Lett. 2021;595(24):3056-3071doi: 10.1002/1873-3468.14219.
Cai, C., Bi, D., Bick, G., Wei, Q., Liu, H., Lu, L., Zhang, X., & Qin, H. (2021). Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis. FEBS letters, 595(24), 3056-3071. https://doi.org/10.1002/1873-3468.14219
Cai, Chunmiao, et al. "Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis." FEBS letters vol. 595,24 (2021): 3056-3071. doi: https://doi.org/10.1002/1873-3468.14219
Cai C, Bi D, Bick G, Wei Q, Liu H, Lu L, Zhang X, Qin H. Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis. FEBS Lett. 2021 Dec;595(24):3056-3071. doi: 10.1002/1873-3468.14219. Epub 2021 Nov 22. PMID: 34719039.
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FEBS Lett. 2021 Dec;595(24):3056-3071. doi: 10.1002/1873-3468.14219. Epub 2021 Nov 22.

Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis.

FEBS letters

Chunmiao Cai, Dexi Bi, Gregory Bick, Qing Wei, Hu Liu, Ling Lu, Xiaoting Zhang, Huanlong Qin

Affiliations

  1. Department of Pathology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
  2. Department of Cancer Biology, University of Cincinnati College of Medicine, OH, USA.
  3. Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

PMID: 34719039 DOI: 10.1002/1873-3468.14219

Abstract

Super-enhancers (SEs) play essential roles in colorectal cancer (CRC) progression. However, how the SE landscape is orchestrated by transcriptional regulators and evolves is not clear. Using de novo motif analysis, we show that the hepatocyte nuclear factor 1 (HNF1)-binding motif is enriched in SEs in cell lines derived from liver metastases, but not in those from primary tumors. This finding was further validated by extending the method to pancreatic cancer and a pair of isogenic CRC lines. Next, we revealed HNF1-alpha (HNF1A) was majorly expressed and upregulated in CRC liver metastatic cell lines. Clinically, HNF1A was remarkably upregulated in synchronous liver metastases as compared to localized tumors. Collectively, our study implicates HNF1A as a key regulator in shaping the SE landscape in CRC liver metastasis.

© 2021 Federation of European Biochemical Societies.

Keywords: CRC liver metastasis; HNF1 motif; SE landscape; transcriptional regulator

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