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Sundar R, Liu DH, Hutchins GG, et al. Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination. Gut. 2020;70(10):1823-1832doi: 10.1136/gutjnl-2020-320805.
Sundar, R., Liu, D. H., Hutchins, G. G., Slaney, H. L., Silva, A. N., Oosting, J., Hayden, J. D., Hewitt, L. C., Ng, C. C., Mangalvedhekar, A., Ng, S. B., Tan, I. B., Tan, P., & Grabsch, H. I. (2021). Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination. Gut, 70(10), 1823-1832. https://doi.org/10.1136/gutjnl-2020-320805
Sundar, Raghav, et al. "Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination." Gut vol. 70,10 (2021): 1823-1832. doi: https://doi.org/10.1136/gutjnl-2020-320805
Sundar R, Liu DH, Hutchins GG, Slaney HL, Silva AN, Oosting J, Hayden JD, Hewitt LC, Ng CC, Mangalvedhekar A, Ng SB, Tan IB, Tan P, Grabsch HI. Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination. Gut. 2021 Oct;70(10):1823-1832. doi: 10.1136/gutjnl-2020-320805. Epub 2020 Nov 23. PMID: 33229445; PMCID: PMC8458060.
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Gut. 2021 Oct;70(10):1823-1832. doi: 10.1136/gutjnl-2020-320805. Epub 2020 Nov 23.

Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination.

Gut

Raghav Sundar, Drolaiz Hw Liu, Gordon Ga Hutchins, Hayley L Slaney, Arnaldo Ns Silva, Jan Oosting, Jeremy D Hayden, Lindsay C Hewitt, Cedric Cy Ng, Amrita Mangalvedhekar, Sarah B Ng, Iain Bh Tan, Patrick Tan, Heike I Grabsch

Affiliations

  1. Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore.
  2. Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.
  3. Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  4. The N.1 Institute for Health, National University of Singapore, Singapore.
  5. Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, The Netherlands.
  6. Division of Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, West Yorkshire, UK.
  7. Department of Surgery, University of Cambridge, Cambridge University Hospitals, Addenbrookes, Cambridge, UK.
  8. Department of Pathology, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands.
  9. Department of Upper Gastrointestinal Surgery, Institute of Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  10. Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre Singapore, Singapore.
  11. Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.
  12. Division of Medical Oncology, National Cancer Centre Singapore, Singapore.
  13. Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore [email protected] [email protected].
  14. SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.
  15. Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  16. Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, The Netherlands [email protected] [email protected].

PMID: 33229445 PMCID: PMC8458060 DOI: 10.1136/gutjnl-2020-320805

Abstract

OBJECTIVE: Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed to study ITH of primary GCs and matched lymph node metastasis (LN

DESIGN: GC resection samples were annotated to identify primary tumour superficial (PT

RESULTS: NanoString profiling of 64 GCs revealed no differences between PT

CONCLUSION: In GC, regional lymph node metastases are likely to originate from deeper subregions of the primary tumour. Future clinical trials of novel targeted therapies must consider assessment of deeper subregions of the primary tumour and/or metastases as several therapeutically relevant genes are only mutated, overexpressed or amplified in these regions.

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: endoscopy; gastric cancer; histopathology; molecular pathology

Conflict of interest statement

Competing interests: PT has stock and other ownership interests in Tempus Healthcare, research funding from Kyowa Hakko Kirin and Thermo Fisher Scientific, and patents/other intellectual property thro

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