J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20211971. Epub 2021 Oct 29.
The Journal of experimental medicine
Victoria M Hallisey, Susan R Schwab
PMID: 34714328 PMCID: PMC8574975 DOI: 10.1084/jem.20211971
In this elegant study, Evrard et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210116) find that sphingosine 1-phosphate receptor 5 (S1PR5) powerfully impairs tissue-resident memory T cell (TRM) formation, and that tissue-derived TGF-β limits S1pr5 expression by infiltrating T cells.
© 2021 Hallisey and Schwab.