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Flatley C, Sole-Navais P, Vaudel M, et al. Placental weight centiles adjusted for age, parity and fetal sex. Placenta. 2021;117:87-94doi: 10.1016/j.placenta.2021.10.011.
Flatley, C., Sole-Navais, P., Vaudel, M., Helgeland, �. �., Modzelewska, D., Johansson, S., Jacobsson, B., & Njølstad, P. (2021). Placental weight centiles adjusted for age, parity and fetal sex. Placenta, 11787-94. https://doi.org/10.1016/j.placenta.2021.10.011
Flatley, Christopher, et al. "Placental weight centiles adjusted for age, parity and fetal sex." Placenta vol. 117 (2021): 87-94. doi: https://doi.org/10.1016/j.placenta.2021.10.011
Flatley C, Sole-Navais P, Vaudel M, Helgeland Ø, Modzelewska D, Johansson S, Jacobsson B, Njølstad P. Placental weight centiles adjusted for age, parity and fetal sex. Placenta. 2021 Oct 23;117:87-94. doi: 10.1016/j.placenta.2021.10.011. Epub 2021 Oct 23. PMID: 34773745.
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Placenta. 2021 Oct 23;117:87-94. doi: 10.1016/j.placenta.2021.10.011. Epub 2021 Oct 23.

Placental weight centiles adjusted for age, parity and fetal sex.

Placenta

Christopher Flatley, Pol Sole-Navais, Marc Vaudel, Øyvind Helgeland, Dominika Modzelewska, Stefan Johansson, Bo Jacobsson, Pål Njølstad

Affiliations

  1. Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: [email protected].
  2. Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  3. Center of Diabetes Research, Department of Clinical Science, University of Bergen, Children and Youth Hospital, Bergen, Norway.
  4. Center of Diabetes Research, Department of Clinical Science, University of Bergen, Children and Youth Hospital, Bergen, Norway; Division of Health Data and Digitalization, Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway.
  5. Center of Diabetes Research, Department of Clinical Science, University of Bergen, Children and Youth Hospital, Bergen, Norway; Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
  6. Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Division of Health Data and Digitalization, Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway; Region Västra Götaland, Sahlgrenska University Hospital, Department of Obstetrics and Gynecology, Gothenburg, Sweden.
  7. Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway; Department of Pediatrics and Adolescents, Haukeland University Hospital, Bergen, Norway.

PMID: 34773745 DOI: 10.1016/j.placenta.2021.10.011

Abstract

INTRODUCTION: The weight of the placenta can be indicative of efficacy in nutrient and oxygen supply. Furthermore, it has been suggested that a measure of the placenta's ability to adequately supply nutrients to the fetus can be found in the relationship between birth weight and placental weight expressed as a ratio. Our aim was to develop age adjusted placenta weight and birth weight to placenta weight ratio reference curves that are stratified by maternal parity and fetal sex.

METHODS: We included singleton, non-anomalous births with a gestational age inclusive of 28 + 0 weeks to 42 + 6 weeks. Excluded were pregnancies of multiplicity, fetuses with congenital abnormalities, stillbirths and pregnancies that had placental complications (ie placenta previa or abruption). Generalised additive model for location, shape and scale (GAMLSS) was used to fit reference curves.

RESULTS: We stratified 97,882 pregnancies by maternal nulliparity status and fetal sex. Extensive assessment model goodness-of-fit showed appropriate modeling and accurate fit to the four parameters of distribution. Our results show accurate model fit of the reference curves to the data. We demonstrated that the influence that parity has on the placenta weight is far greater than that exerted by fetal sex, and that the difference is dependent on gestational age.

DISCUSSION: This is the largest presentation of age and parity adjusted placenta weight and feto-placental weight ratio reference ranges to date. The difference observed between nulliparous and multiparous pregnancies could be explained by biological memory and the remnants of maternal endo-myometrial vascularity after the first pregnancy.

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords: Father and Child cohort study; Feto-placenta ratio; Norwegian Mother; Parity; Placenta; Placenta weight; Reference curves

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