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Chakraborty R, Landis EG, Mazade R, et al. Melanopsin modulates refractive development and myopia. Exp Eye Res. 2021;214:108866doi: 10.1016/j.exer.2021.108866.
Chakraborty, R., Landis, E. G., Mazade, R., Yang, V., Strickland, R., Hattar, S., Stone, R. A., Iuvone, P. M., & Pardue, M. T. (2021). Melanopsin modulates refractive development and myopia. Experimental eye research, 214108866. https://doi.org/10.1016/j.exer.2021.108866
Chakraborty, Ranjay, et al. "Melanopsin modulates refractive development and myopia." Experimental eye research vol. 214 (2021): 108866. doi: https://doi.org/10.1016/j.exer.2021.108866
Chakraborty R, Landis EG, Mazade R, Yang V, Strickland R, Hattar S, Stone RA, Iuvone PM, Pardue MT. Melanopsin modulates refractive development and myopia. Exp Eye Res. 2021 Nov 25;214:108866. doi: 10.1016/j.exer.2021.108866. Epub 2021 Nov 25. PMID: 34838844.
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Exp Eye Res. 2021 Nov 25;214:108866. doi: 10.1016/j.exer.2021.108866. Epub 2021 Nov 25.

Melanopsin modulates refractive development and myopia.

Experimental eye research

Ranjay Chakraborty, Erica G Landis, Reece Mazade, Victoria Yang, Ryan Strickland, Samer Hattar, Richard A Stone, P Michael Iuvone, Machelle T Pardue

Affiliations

  1. Department of Ophthalmology, Emory University School of Medicine, 1365B Clifton Rd NE, Atlanta, GA, 30322, United States; Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, 1670 Clairmont Rd, Decatur, GA, 30033, United States; College of Nursing and Health Sciences, Optometry and Vision Science, Flinders University, Bedford Park, SA, 5001, Adelaide, Australia; Caring Futures Institute, Flinders University, Bedford Park, SA, 5042, Adelaide, Australia.
  2. Department of Ophthalmology, Emory University School of Medicine, 1365B Clifton Rd NE, Atlanta, GA, 30322, United States; Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, 1670 Clairmont Rd, Decatur, GA, 30033, United States; Neuroscience Program, Emory University School of Medicine, 1365 Clifton Rd NE, Atlanta, GA, 30322, United States.
  3. Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, 1670 Clairmont Rd, Decatur, GA, 30033, United States; Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr, Atlanta, GA, 30332, United States.
  4. Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, 1670 Clairmont Rd, Decatur, GA, 30033, United States; Neuroscience Program, Emory University School of Medicine, 1365 Clifton Rd NE, Atlanta, GA, 30322, United States.
  5. Section on Light and Circadian Rhythms, NIMH, NIH, 9000 Rockville Pike, Bethesda, MD, USA, 20892.
  6. Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
  7. Department of Ophthalmology, Emory University School of Medicine, 1365B Clifton Rd NE, Atlanta, GA, 30322, United States; Department of Pharmacology, Emory University School of Medicine, 1365B Clifton Rd NE, Atlanta, GA, 30322, United States.
  8. Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, 1670 Clairmont Rd, Decatur, GA, 30033, United States; Neuroscience Program, Emory University School of Medicine, 1365 Clifton Rd NE, Atlanta, GA, 30322, United States; Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr, Atlanta, GA, 30332, United States. Electronic address: [email protected].

PMID: 34838844 DOI: 10.1016/j.exer.2021.108866

Abstract

Myopia, or nearsightedness, is the most common form of refractive abnormality and is characterized by excessive ocular elongation in relation to ocular power. Retinal neurotransmitter signaling, including dopamine, is implicated in myopic ocular growth, but the visual pathways that initiate and sustain myopia remain unclear. Melanopsin-expressing retinal ganglion cells (mRGCs), which detect light, are important for visual function, and have connections with retinal dopamine cells. Here, we investigated how mRGCs influence normal and myopic refractive development using two mutant mouse models: Opn4

Published by Elsevier Ltd.

Keywords: 3,4-Dihydroxyphenylacetic acid (DOPAC); Dopamine; L-3,4-dihydroxyphenylalanine (L-DOPA); Melanopsin retinal ganglion cells (mRGCs); Opn4

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