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Zapata-Muñoz J, Villarejo-Zori B, Largo-Barrientos P, et al. Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health. Cell Stress. 2021;5(7):99-118doi: 10.15698/cst2021.07.253.
Zapata-Muñoz, J., Villarejo-Zori, B., Largo-Barrientos, P., & Boya, P. (2021). Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health. Cell stress, 5(7), 99-118. https://doi.org/10.15698/cst2021.07.253
Zapata-Muñoz, Juan, et al. "Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health." Cell stress vol. 5,7 (2021): 99-118. doi: https://doi.org/10.15698/cst2021.07.253
Zapata-Muñoz J, Villarejo-Zori B, Largo-Barrientos P, Boya P. Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health. Cell Stress. 2021 Jun 29;5(7):99-118. doi: 10.15698/cst2021.07.253. eCollection 2021 Jul. PMID: 34308255; PMCID: PMC8283300.
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Cell Stress. 2021 Jun 29;5(7):99-118. doi: 10.15698/cst2021.07.253. eCollection 2021 Jul.

Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health.

Cell stress

Juan Zapata-Muñoz, Beatriz Villarejo-Zori, Pablo Largo-Barrientos, Patricia Boya

Affiliations

  1. Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain.
  2. Universiteit van Amsterdam, Amsterdam, The Netherlands.

PMID: 34308255 PMCID: PMC8283300 DOI: 10.15698/cst2021.07.253

Abstract

Autophagy is a critical cellular process by which biomolecules and cellular organelles are degraded in an orderly manner inside lysosomes. This process is particularly important in neurons: these post-mitotic cells cannot divide or be easily replaced and are therefore especially sensitive to the accumulation of toxic proteins and damaged organelles. Dysregulation of neuronal autophagy is well documented in a range of neurodegenerative diseases. However, growing evidence indicates that autophagy also critically contributes to neurodevelopmental cellular processes, including neurogenesis, maintenance of neural stem cell homeostasis, differentiation, metabolic reprogramming, and synaptic remodelling. These findings implicate autophagy in neurodevelopmental disorders. In this review we discuss the current understanding of the role of autophagy in neurodevelopment and neurodevelopmental disorders, as well as currently available tools and techniques that can be used to further investigate this association.

Copyright: © 2021 Zapata-Muñoz et al.

Keywords: autism spectrum disorder; developmental disorders; neurodevelopment; neurogenesis; neuronal autophagy

Conflict of interest statement

Conflict of Interest: The author's declare no conflict of interest.

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