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Uusitalo K, Haataja L, Saunavaara V, et al. Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm. Pediatr Neurol. 2021;123:21-29doi: 10.1016/j.pediatrneurol.2021.07.001.
Uusitalo, K., Haataja, L., Saunavaara, V., Lind, A., Vorobyev, V., Tilli, J., Parkkola, R., Setänen, S. (2021). Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm. Pediatric neurology, 12321-29. https://doi.org/10.1016/j.pediatrneurol.2021.07.001
Uusitalo, Karoliina, et al. "Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm." Pediatric neurology vol. 123 (2021): 21-29. doi: https://doi.org/10.1016/j.pediatrneurol.2021.07.001
Uusitalo K, Haataja L, Saunavaara V, Lind A, Vorobyev V, Tilli J, Parkkola R, Setänen S. Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm. Pediatr Neurol. 2021 Oct;123:21-29. doi: 10.1016/j.pediatrneurol.2021.07.001. Epub 2021 Jul 10. PMID: 34339952.
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Pediatr Neurol. 2021 Oct;123:21-29. doi: 10.1016/j.pediatrneurol.2021.07.001. Epub 2021 Jul 10.

Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm.

Pediatric neurology

Karoliina Uusitalo, Leena Haataja, Virva Saunavaara, Annika Lind, Victor Vorobyev, Joni Tilli, Riitta Parkkola, Sirkku Setänen,

Affiliations

  1. Department of Pediatric Neurology, University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland. Electronic address: [email protected].
  2. University of Helsinki and Helsinki University Hospital, Children's Hospital, and Pediatric Research Center, Helsinki, Finland.
  3. Division of Medical Imaging, Department of Medical Physics, Turku University Hospital, Turku, Finland; Turku PET Centre, Turku University Hospital, Turku, Finland.
  4. Attentio Ltd, Turku, Finland; Department of Psychology, Åbo Akademi University, Turku, Finland.
  5. Turku University Hospital, Turku, Finland; Department of Radiology, University of Turku, Turku, Finland.
  6. Department of Pediatric Neurology, University of Turku, Turku, Finland.
  7. Department of Pediatric Neurology, University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.

PMID: 34339952 DOI: 10.1016/j.pediatrneurol.2021.07.001

Abstract

BACKGROUND: Fine motor and coordination problems are frequently reported among adolescents born preterm. We aimed to assess performance in hand coordination tasks and to compare concurrent brain activation between adolescents born very preterm and at term at 13 years.

METHODS: A total of 34 right-handed adolescents born very preterm (gestational age less than 32 weeks/birth weight ≤1500 grams) and 37 controls born at term during 2003 to 2006 in Turku University Hospital, Finland, were recruited. At 13 years, finger opposition and diadochokinesis were assessed, and brain functional magnetic resonance imaging data were acquired while the adolescents performed unimanual hand coordination tasks in response to visual cue.

RESULTS: Adolescents born very preterm performed similar to controls in hand coordination tasks. The very preterm group evoked greater brain activation than the controls in the right precentral gyrus and in the right postcentral gyrus during left-hand finger opposition and in the right postcentral gyrus during left-hand diadochokinesis. Within the very preterm group, lower gestational age was associated with reduced activation in the left superior parietal lobule during right-hand diadochokinesis. Regarding left-hand tasks, lower gestational age was associated with stronger activation in the right cerebellar lobule V and left cerebellar lobule VI during finger opposition and stronger activation in the right superior parietal lobule during diadochokinesis.

CONCLUSIONS: Very preterm birth affected hand coordination-related brain activation. Most of the effects were found for nondominant hand. Clinical performance during the hand coordination tasks was similar in adolescents born very preterm and controls.

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Keywords: Fine motor; Follow-up; Prematurity; fMRI

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