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Pin G, Coupé P, Nadal L, et al. Distinct Hippocampal Subfields Atrophy in Older People With Vascular Brain Injuries. Stroke. 2021;52(5):1741-1750doi: 10.1161/STROKEAHA.120.031743.
Pin, G., Coupé, P., Nadal, L., Manjon, J. V., Helmer, C., Amieva, H., Mazoyer, B., Dartigues, J. F., Catheline, G., & Planche, V. (2021). Distinct Hippocampal Subfields Atrophy in Older People With Vascular Brain Injuries. Stroke, 52(5), 1741-1750. https://doi.org/10.1161/STROKEAHA.120.031743
Pin, Grégoire, et al. "Distinct Hippocampal Subfields Atrophy in Older People With Vascular Brain Injuries." Stroke vol. 52,5 (2021): 1741-1750. doi: https://doi.org/10.1161/STROKEAHA.120.031743
Pin G, Coupé P, Nadal L, Manjon JV, Helmer C, Amieva H, Mazoyer B, Dartigues JF, Catheline G, Planche V. Distinct Hippocampal Subfields Atrophy in Older People With Vascular Brain Injuries. Stroke. 2021 May;52(5):1741-1750. doi: 10.1161/STROKEAHA.120.031743. Epub 2021 Mar 04. PMID: 33657856.
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Stroke. 2021 May;52(5):1741-1750. doi: 10.1161/STROKEAHA.120.031743. Epub 2021 Mar 04.

Distinct Hippocampal Subfields Atrophy in Older People With Vascular Brain Injuries.

Stroke

Grégoire Pin, Pierrick Coupé, Louis Nadal, Jose V Manjon, Catherine Helmer, Hélène Amieva, Bernard Mazoyer, Jean-François Dartigues, Gwénaëlle Catheline, Vincent Planche

Affiliations

  1. University of Bordeaux, CNRS, UMR 5293, Institut des Maladies Neurodégénératives, France (G.P., L.N., B.M., V.P.).
  2. Centre Mémoire de Ressources et de Recherches, Pôle de Neurosciences Cliniques, CHU de Bordeaux, France (G.P., L.N., J.-F.D., V.P.).
  3. University of Bordeaux, CNRS, Bordeaux INP, Laboratoire Bordelais de Recherche en Informatique, UMR 5800, PICTURA, Talence, France (P.C.).
  4. Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Spain (J.V.M.).
  5. University of Bordeaux, Inserm, UMR 1219, Bordeaux Population Health Research Center, France (C.H., H.A., J.-F.D.).
  6. EPHE, PSL, Bordeaux, France (G.C.).
  7. University of Bordeaux, CNRS, UMR 5287, Institut de Neurosciences cognitives et intégratives d'Aquitaine, France (G.C.).

PMID: 33657856 DOI: 10.1161/STROKEAHA.120.031743

Abstract

BACKGROUND AND PURPOSE: Many neurological or psychiatric diseases affect the hippocampus during aging. The study of hippocampal regional vulnerability may provide important insights into the pathophysiological mechanisms underlying these processes; however, little is known about the specific impact of vascular brain damage on hippocampal subfields atrophy.

METHODS: To analyze the effect of vascular injuries independently of other pathological conditions, we studied a population-based cohort of nondemented older adults, after the exclusion of people who were diagnosed with neurodegenerative diseases during the 14-year clinical follow-up period. Using an automated segmentation pipeline, 1.5T-magnetic resonance imaging at inclusion and 4 years later were assessed to measure both white matter hyperintensities and hippocampal subfields volume. Annualized rates of white matter hyperintensity progression and annualized rates of hippocampal subfields atrophy were then estimated in each participant.

RESULTS: We included 249 participants in our analyses (58% women, mean age 71.8, median Mini-Mental State Evaluation 29). The volume of the subiculum at baseline was the only hippocampal subfield volume associated with total, deep/subcortical, and periventricular white matter hyperintensity volumes, independently of demographic variables and vascular risk factors (β=-0.17,

CONCLUSIONS: These cross-sectional and longitudinal findings highlight the links between vascular brain injuries and a differential vulnerability of the subiculum within the hippocampal loop, unbiased of the effect of neurodegenerative diseases, and particularly when vascular injuries affect deep/subcortical structures.

Keywords: aging; atrophy; demography; hippocampus; risk factors

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