Mol Nutr Food Res. 2021 Dec 09;e2100978. doi: 10.1002/mnfr.202100978. Epub 2021 Dec 09.

Colonic Delivery of α-Linolenic Acid by an Advanced Nutrient Delivery System Prolongs Glucagon-Like Peptide-1 Secretion and Inhibits Food Intake in Mice.

Molecular nutrition & food research

Remi Kamakura, Ghulam Shere Raza, Ermei Mäkilä, Joakim Riikonen, Miia Kovalainen, Yoichi Ueta, Vesa-Pekka Lehto, Jarno Salonen, Karl-Heinz Herzig

PMID: 34882959 DOI: 10.1002/mnfr.202100978

Abstract

SCOPE: Nutrients stimulate the secretion of glucagon-like peptide-1 (GLP-1), an incretin hormone, secreted from enteroendocrine L-cells which decreases food intake. Thus, GLP-1 analogs are approved for the treatment of obesity, yet cost and side effects limit their use. L-cells are mainly localized in the distal ileum and colon, which hinders the utilization of nutrients targeting GLP-1 secretion. This study proposes a controlled delivery system for nutrients, inducing a prolonged endogenous GLP-1 release which results in a decrease food intake.

METHODS AND RESULTS: α-Linolenic acid (αLA) was loaded into thermally hydrocarbonized porous silicon (THCPSi) particles. In vitro characterization and in vivo effects of αLA loaded particles on GLP-1 secretion and food intake were studied in mice. A total of 40.4 ± 3.2% of loaded αLA is released from particles into biorelevant buffer over 24 h, and αLA loaded THCPSi significantly increased in vitro GLP-1 secretion. Single-dose orally given αLA loaded mesoporous particles increased plasma active GLP-1 levels at 3 and 4 h and significantly reduced the area under the curve of 24 h food intake in mice.

CONCLUSIONS: αLA loaded THCPSi particles could be used to endogenously stimulate sustain gastrointestinal hormone release and reduce food intake.

© 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.

Keywords: GLP-1; enteroendocrine cells; food intake; mesoporous silicon particles; α-Linolenic acid

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Publication Types

• Journal Article

Grant support

• Jalmari ja Rauha Ahokkaan Säätiö
• Pohjois-Pohjanmaan Rahasto
• Suomen Kulttuurirahasto