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Curr Opin Neurobiol. 2021 Dec;71:164-169. doi: 10.1016/j.conb.2021.11.009. Epub 2021 Nov 27.

Has the hippocampus really forgotten about space?.

Current opinion in neurobiology

Judit Fiedler, Elvira De Leonibus, Alessandro Treves

Affiliations

  1. SISSA - Cognitive Neuroscience, Trieste, Italy.
  2. Institute of Cellular Biology and Biochemistry, IBBC-CNR, Naples, Italy.
  3. SISSA - Cognitive Neuroscience, Trieste, Italy; Kavli Centre for Neural Computation, NTNU, Trondheim, Norway. Electronic address: [email protected].

PMID: 34847486 DOI: 10.1016/j.conb.2021.11.009

Abstract

Several lines of evidence, including the discovery of place cells, have contributed to the notion that the hippocampus serves primarily to navigate the environment, as a repository of spatial memories, like a drawer full of charts; and that in some species it has exapted on this original one an episodic memory function. We argue that recent evidence questions the primacy of space, and points at memory load, whether spatial or not, as the challenge that mammalian hippocampal circuitry has evolved to meet.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Conflict of interest statement

Conflict of interest statement Nothing declared.

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