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Tam Toan TT, Nguyen DM, Dung DM, et al. Electrochemical sensor to detect terbutaline in biological samples by a green agent. Chemosphere. 2021;289:133171doi: 10.1016/j.chemosphere.2021.133171.
Tam Toan, T. T., Nguyen, D. M., Dung, D. M., Ngoc Hoa, D. T., Thanh Nhi, L. T., Thanh, N. M., Dung, N. N., Vasseghian, Y., & Golzadeh, N. (2021). Electrochemical sensor to detect terbutaline in biological samples by a green agent. Chemosphere, 289133171. https://doi.org/10.1016/j.chemosphere.2021.133171
Tam Toan, Tran Thanh, et al. "Electrochemical sensor to detect terbutaline in biological samples by a green agent." Chemosphere vol. 289 (2021): 133171. doi: https://doi.org/10.1016/j.chemosphere.2021.133171
Tam Toan TT, Nguyen DM, Dung DM, Ngoc Hoa DT, Thanh Nhi LT, Thanh NM, Dung NN, Vasseghian Y, Golzadeh N. Electrochemical sensor to detect terbutaline in biological samples by a green agent. Chemosphere. 2021 Dec 04;289:133171. doi: 10.1016/j.chemosphere.2021.133171. Epub 2021 Dec 04. PMID: 34875292.
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Chemosphere. 2021 Dec 04;289:133171. doi: 10.1016/j.chemosphere.2021.133171. Epub 2021 Dec 04.

Electrochemical sensor to detect terbutaline in biological samples by a green agent.

Chemosphere

Tran Thanh Tam Toan, Do Mai Nguyen, Doan Manh Dung, Dang Thi Ngoc Hoa, Le Thi Thanh Nhi, Nguyen Mau Thanh, Nguyen Nho Dung, Yasser Vasseghian, Nasrin Golzadeh

Affiliations

  1. Dong A University, 50000, Viet Nam.
  2. University of Science, Hue University, 530000, Viet Nam.
  3. Institute of Biotechnology and Environment, Tay Nguyen University, Buon Ma Thuot, 630000, Viet Nam.
  4. University of Medicine and Pharmacy, Hue University, 49000, Hue, Viet Nam.
  5. Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, Da Nang, 550000, Viet Nam; Faculty of Natural Sciences, Duy Tan University, 550000, Viet Nam.
  6. Faculty of Natural Sciences, Quang Binh University, 51000, Quang Binh, Viet Nam.
  7. Danang Sport University, 50000, Viet Nam. Electronic address: [email protected].
  8. Department of Chemical Engineering, Quchan University of Technology, Quchan, Iran. Electronic address: [email protected].
  9. Science, Technology, Engineering, And Mathematics (STEM) Knowledge Translations Institute, Montreal, Quebec, Canada.

PMID: 34875292 DOI: 10.1016/j.chemosphere.2021.133171

Abstract

In this research, reduced graphene oxide (RGO) which is a form of graphene oxide (GO) was formed through a reduction process using a "green agent" called Ascorbic acid (AA). RGO was then modified on the surface of the glassy carbon electrode (GCE) to generate RGO/GCE (an advanced electrode). The RGO/GCE was then used to detect Terbutaline (TB) in urine samples of volunteer athletes (n = 5) using well-known spectrophotometric analyses including X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible Spectroscopy (UV-Vis), and Raman and electrochemical methods using voltammetric analyses such as differential pulse anodic stripping voltammetry (DP-ASV) and cyclic voltammetry (CV). Comparing various analysis methods using RGO/GCE to detect TB in human urine samples, voltammetric analysis specifically DP-ASV demonstrated higher sensitivity and selectivity in detecting TB than spectrophotometric analyses. Thus, in this study, several factors that would affect the voltammetric signals such as pH and interferents were evaluated and the electroactive surface area was also calculated. Our findings indicated that the RGO/GCE showed excellent repeatability, reproducibility, and long-term stability suggesting that TB could be detected more effectively using RGO/GCE than bare GCE. The detection limit of 0.0052 μM achieved in this study indicated that RGO/GCE can effectively detect TB in human urine while demonstrating reasonable selectivity and sensitivity.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Ascorbic acid; Different pulse voltammetry; Doping; Reduced graphene oxide; Terbutaline

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