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Zenebe Y, Akele B, W/Selassie M, et al. Prevalence and determinants of depression among old age: a systematic review and meta-analysis. Ann Gen Psychiatry. 2021;20(1):55doi: 10.1186/s12991-021-00375-x.
Zenebe, Y., Akele, B., W/Selassie, M., & Necho, M. (2021). Prevalence and determinants of depression among old age: a systematic review and meta-analysis. Annals of general psychiatry, 20(1), 55. https://doi.org/10.1186/s12991-021-00375-x
Zenebe, Yosef, et al. "Prevalence and determinants of depression among old age: a systematic review and meta-analysis." Annals of general psychiatry vol. 20,1 (2021): 55. doi: https://doi.org/10.1186/s12991-021-00375-x
Zenebe Y, Akele B, W/Selassie M, Necho M. Prevalence and determinants of depression among old age: a systematic review and meta-analysis. Ann Gen Psychiatry. 2021 Dec 18;20(1):55. doi: 10.1186/s12991-021-00375-x. PMID: 34922595.
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Ann Gen Psychiatry. 2021 Dec 18;20(1):55. doi: 10.1186/s12991-021-00375-x.

Prevalence and determinants of depression among old age: a systematic review and meta-analysis.

Annals of general psychiatry

Yosef Zenebe, Baye Akele, Mulugeta W/Selassie, Mogesie Necho

Affiliations

  1. Department of Psychiatry, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia. [email protected].
  2. Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  3. Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
  4. Department of Psychiatry, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

PMID: 34922595 DOI: 10.1186/s12991-021-00375-x

Abstract

BACKGROUND: Depression is a leading cause of disability worldwide and is a major contributor to the overall global burden of disease. It is also one of the most common geriatric psychiatric disorders and a major risk factor for disability and mortality in elderly patients. Even though depression is a common mental health problem in the elderly population, it is undiagnosed in half of the cases. Several studies showed different and inconsistent prevalence rates in the world. Hence, this study aimed to fill the above gap by producing an average prevalence of depression and associated factors in old age.

OBJECTIVE: This study aims to conduct a systematic review and meta-analysis to provide a precise estimate of the prevalence of depression and its determinants among old age.

METHOD: A comprehensive search of PubMed, Scopus, Web of sciences, Google Scholar, and Psych-info from database inception to January 2020. Moreover, the reference list of selected articles was looked at manually to have further eligible articles. The random-effects model was employed during the analysis. Stata-11 was used to determine the average prevalence of depression among old age. A sub-group analysis and sensitivity analysis were also run. A graphical inspection of the funnel plots and Egger's publication bias plot test were checked for the occurrence of publication bias.

RESULT: A search of the electronic and manual system resulted in 1263 articles. Nevertheless, after the huge screening, 42 relevant studies were identified, including, for this meta-analysis, n = 57,486 elderly populations. The average expected prevalence of depression among old age was 31.74% (95% CI 27.90, 35.59). In the sub-group analysis, the pooled prevalence was higher among developing countries; 40.78% than developed countries; 17.05%), studies utilized Geriatrics Depression Scale-30(GDS-30); 40.60% than studies that used GMS; 18.85%, study instrument, and studies having a lower sample size (40.12%) than studies with the higher sample; 20.19%.

CONCLUSION: A high prevalence rate of depression among the old population in the world was unraveled. This study can be considered as an early warning and advised health professionals, health policymakers, and other pertinent stakeholders to take effective control measures and periodic care for the elderly population.

© 2021. The Author(s).

Keywords: Depression; Elderly; Global

References

  1. Singh C, Mathur J, Mishra V, Singh J, Singh R, Garg B, et al. Social Problems of Aged in a rural population. Indian J Community Med. 1995;20(2):24. - PubMed
  2. Tan S. Mental Health and Ageing. Speech by the Minister of Community Development and Consumer Affairs at “The Proclamation of the World Health Mental Day with the Theme Mental Health and Ageing”, Malaysia. 1999. - PubMed
  3. Organization WH. Global health observatory (GHO) data. Life expectancy. World Health Organization, Geneva. http://www.whoint/gho/mortality_burden_disease/life_tables/situation_trends_text/en/ Accessed. 2016;20. - PubMed
  4. Osman C. Physical and psychiatry diseases of aged people in Malaysia: an evaluation in Ampang, Selangor, Malaysia. Sch J App Med Sci. 2015;3(1C):159–66. - PubMed
  5. Bujang MA, Hamid AMA, Zolkepali NA, Mustaâ N, Lazim SSM, Haniff J. Mortality rates by specific age group and gender in Malaysia: Trend of 16 years, 1995 –2010. Journal of Health Informatics in Developing Countries. 2012;6(2). - PubMed
  6. Organization WH. The Global Network for Age-friendly Cities and Communities: Looking back over the last decade, looking forward to the next. World Health Organization, 2018. - PubMed
  7. Rudnicka E, Napierała P, Podfigurna A, Męczekalski B, Smolarczyk R, Grymowicz M. The World Health Organization (WHO) approach to healthy ageing. Maturitas. 2020. - PubMed
  8. Organization WH. Multisectoral action for a life course approach to healthy aging: draft global strategy and plan of action on aging and health. World Health Organization: Geneva, Switzerland. 2016:1–37. - PubMed
  9. Tiple P, Sharma S, Srivastava A. Psychiatric morbidity in geriatric people. Indian J Psychiatry. 2006;48(2):88. - PubMed
  10. Blazer DG, Hybels CF. Origins of depression in later life. Psychol Med. 2005;35(9):1241–52. - PubMed
  11. Flood M, Buckwalter KC. Recommendations for mental health care of older adults: Part 1—an overview of depression and anxiety. J Gerontol Nurs. 2009;35(2):26–34. - PubMed
  12. James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2018;392(10159):1789–858. - PubMed
  13. Moss K, Scogin F, Di Napoli E, Presnell A. A self-help behavioral activation treatment for geriatric depressive symptoms. Aging Ment Health. 2012;16(5):625–35. - PubMed
  14. Blazer DG, Hybels CF, Pieper CF. The association of depression and mortality in elderly persons: a case for multiple, independent pathways. J Gerontol A Biol Sci Med Sci. 2001;56(8):M505–9. - PubMed
  15. Demyttenaere K, Bruffaerts R, Posada-Villa J, Gasquet I, Kovess V, Lepine JP, et al. Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys. JAMA. 2004;291(21):2581–90. - PubMed
  16. Gallo JJ, Lebowitz BD. The epidemiology of common late-life mental disorders in the community: themes for the new century. Psychiatr Serv. 1999;50(9):1158–66. - PubMed
  17. Charney DS, Reynolds CF, Lewis L, Lebowitz BD, Sunderland T, Alexopoulos GS, et al. Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life. Arch Gen Psychiatry. 2003;60(7):664–72. - PubMed
  18. Raviola G, Eustache E, Oswald C, Belkin GS. Mental health response in Haiti in the aftermath of the 2010 earthquake: a case study for building long-term solutions. Harv Rev Psychiatry. 2012;20(1):68–77. - PubMed
  19. Mitchell AJ, Subramaniam H. Prognosis of depression in old age compared to middle age: a systematic review of comparative studies. Am J Psychiatry. 2005;162(9):1588–601. - PubMed
  20. Organization WH. The mental health of older adults: fact Sheet. World Health Organization Media Centre http://www.who.int/mediacenter/factsheets/fs381/en/ Published December. 2017;12. - PubMed
  21. Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, et al. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013. Int J Epidemiol. 2014;43(2):476–93. - PubMed
  22. Patel V, Saxena S. Transforming lives, enhancing communities—innovations in global mental health. N Engl J Med. 2014;370(6):498–501. - PubMed
  23. Mirkena Y, Reta MM, Haile K, Nassir Z, Sisay MM. Prevalence of depression and associated factors among older adults at ambo town, Oromia region, Ethiopia. BMC Psychiatry. 2018;18(1):338. - PubMed
  24. Hasin DS, Goodwin RD, Stinson FS, Grant BF. Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Arch Gen Psychiatry. 2005;62(10):1097–106. - PubMed
  25. Blazer DG. Depression in late life: review and commentary. J Gerontol A Biol Sci Med Sci. 2003;58(3):M249–65. - PubMed
  26. Saxena S, Funk M, Chisholm D. World health assembly adopts comprehensive mental health action plan 2013–2020. Lancet. 2013;381(9882):1970–1. - PubMed
  27. Organization WH. Global health risks: mortality and burden of disease attributable to selected major risks: World Health Organization; 2009. - PubMed
  28. Andreasen P, Lönnroos E, von Euler-Chelpin MC. Prevalence of depression among older adults with dementia living in low-and middle-income countries: a cross-sectional study. Eur J Public Health. 2014;24(1):40–4. - PubMed
  29. Padayachey U, Ramlall S, Chipps J. Depression in older adults: prevalence and risk factors in a primary health care sample. S Afr Fam Pract. 2017;59(2):61–6. - PubMed
  30. Ferrari A, Somerville A, Baxter A, Norman R, Patten S, Vos T, et al. Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature. Psychol Med. 2013;43(3):471. - PubMed
  31. Nicholson IR. New technology, old issues: Demonstrating the relevance of the Canadian Code of Ethics for Psychologists to the ever-sharper cutting edge of technology. Can Psychol. 2011;52(3):215. - PubMed
  32. Souci M, Prince M, Atalay A, Derege K, Stewart R, Nick G, et al. Outcome of major depression in Ethiopia. Br J Psychiatry. 2006;189(3):241–6. - PubMed
  33. Luppa M, Heinrich S, Matschinger H, Sandholzer H, Angermeyer MC, König H-H, et al. Direct costs associated with depression in old age in Germany. J Affect Disord. 2008;105(1–3):195–204. - PubMed
  34. Lemma A, Target M, Fonagy P. The development of a brief psychodynamic protocol for depression: Dynamic Interpersonal Therapy (DIT). Psychoanal Psychother. 2010;24(4):329–46. - PubMed
  35. Gonzalez VM, Goeppinger J, Lorig K. Four psychosocial theories and their application to patient education and clinical practice. Arthritis Rheum. 1990;3(3):132–43. - PubMed
  36. Dwivedi Y. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatric Dis Treat. 2009;5:433–49. - PubMed
  37. Munsawaengsub C. Factors influencing the mental health of the elderly in Songkhla, Thailand. J Med Assoc Thai. 2012;95(6):S8–15. - PubMed
  38. Sidik SM, Rampal L, Afifi M. Physical and mental health problems of the elderly in a rural community of Sepang, Selangor. Malays J Med Sci. 2004;11(1):52. - PubMed
  39. Cole MG, Dendukuri N. Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. Am J Psychiatry. 2003;160(6):1147–56. - PubMed
  40. Sengupta P, Benjamin AI. Prevalence of depression and associated risk factors among the elderly in urban and rural field practice areas of a tertiary care institution in Ludhiana. İndian J Public Health. 2015;59(1):3. - PubMed
  41. Velázquez-Brizuela IE, Ortiz GG, Ventura-Castro L, Árias-Merino ED, Pacheco-Moisés FP, Macías-Islas MA. Prevalence of dementia, emotional state and physical performance among older adults in the metropolitan area of Guadalajara, Jalisco, Mexico. Curr Gerontol Geriatr Res. 2014;2014:387528. - PubMed
  42. Yaka E, Keskinoglu P, Ucku R, Yener GG, Tunca Z. Prevalence and risk factors of depression among community-dwelling elderly. Arch Gerontol Geriatr. 2014;59(1):150–4. - PubMed
  43. Djernes JK. Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand. 2006;113(5):372–87. - PubMed
  44. Akbaş E, Yiğitoğlu GT, Çunkuş N. Yaşlılıkta Sosyal İzolasyon ve Yalnızlık. OPUS Uluslararası Toplum Araştırmaları Dergisi. 15(26):4540–62. - PubMed
  45. Roberts RE, Kaplan GA, Shema SJ, Strawbridge WJ. Does growing old increase the risk for depression. 1997. - PubMed
  46. Blazer D, Burchett B, Service C, George LK. The association of age and depression among the elderly: an epidemiologic exploration. J Gerontol. 1991;46(6):M210–5. - PubMed
  47. Heun R, Hein S. Risk factors of major depression in the elderly. Eur Psychiatry. 2005;20(3):199–204. - PubMed
  48. Weyerer S, Eifflaender-Gorfer S, Wiese B, Luppa M, Pentzek M, Bickel H, et al. Incidence and predictors of depression in non-demented primary care attenders aged 75 years and older: results from a 3-year follow-up study. Age Aging. 2013;42(2):173–80. - PubMed
  49. Koenig HG, Meador KG, Cohen HJ, Blazer DG. Depression in elderly hospitalized patients with medical illness. Arch Intern Med. 1988;148(9):1929–36. - PubMed
  50. Kugbey N, Nortu TA, Akpalu B, Ayanore MA, Zotor FB. Prevalence of geriatric depression in a community sample in Ghana: analysis of associated risk and protective factors. Arch Gerontol Geriatr. 2018;78:171–6. - PubMed
  51. VYas J, MNAMS D. NIraj Ahuja MD: Textbook of Postgraduate Psychiatry, Jaypee Brothers Medical Publishers (P) Ltd. New Delhi Second edtion. 1999. - PubMed
  52. Veras RP, Coutinho ED. Estudo de prevalência de depressão e síndrome cerebral orgânica na população de idosos, Brasil. Rev Saude Publica. 1991;25:209–17. - PubMed
  53. Donald M. Psychiatric illnesses in elderly. J Gerontol. 1992;47:142–50. - PubMed
  54. Abbasian M, Pourshahbaz A, Taremian F, Poursharifi H. The role of psychological factors in non-suicidal self-injury of female adolescents. Iran J Psychiatry and Behav Sci. 2021;15(1). - PubMed
  55. Lin J-H, Huang M-W, Wang D-W, Chen Y-M, Lin C-S, Tang Y-J, et al. Late-life depression and quality of life in a geriatric evaluation and management unit: an exploratory study. BMC Geriatr. 2014;14(1):1–7. - PubMed
  56. McDOUGALL FA, Kvaal K, Matthews FE, Paykel E, Jones PB, Dewey ME, et al. Prevalence of depression in older people in England and Wales: the MRC CFA Study. Psychol Med. 2007;37(12):1787. - PubMed
  57. Choulagai P, Sharma C, Choulagai B. Prevalence and associated factors of depression among elderly population living in geriatric homes in Kathmandu Valley. J Inst Med Nepal. 2013;35(1):39–44. - PubMed
  58. Wilson K, Taylor S, Copeland J, Chen R, McCracken C. Socio-economic deprivation and the prevalence and prediction of depression in older community residents. Br J Psychiatry. 1999;175(6):549–53. - PubMed
  59. Valvanne J, Juva K, Erkinjuntti T, Tilvis R. Major depression in the elderly: a population study in Helsinki. Int Psychogeriatr. 1996;8(3):437–43. - PubMed
  60. Byers AL, Yaffe K. Depression, and risk of developing dementia. Nat Rev Neurol. 2011;7(6):323. - PubMed
  61. Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. The Lancet. 2007;370(9590):851–8. - PubMed
  62. Sartorius N, Üstün TB, Silva J-AC, Goldberg D, Lecrubier Y, Ormel J, et al. An international study of psychological problems in primary care: a preliminary report from the World Health Organization Collaborative Project Psychological Problems in General Health Care. Arch Gen Psychiatry. 1993;50(10):819–24. - PubMed
  63. Beekman AT, Deeg DJ, van Tilburg T, Smit JH, Hooijer C, van Tilburg W. Major and minor depression in later life: a study of prevalence and risk factors. J Affect Disord. 1995;36(1–2):65–75. - PubMed
  64. Blazer DG, Sachs-Ericsson N, Hybels CF. Perception of unmet basic needs as a predictor of depressive symptoms among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2007;62(2):191–5. - PubMed
  65. Bitew T. Prevalence and risk factors of depression in Ethiopia: a review. Ethiop J Health Sci. 2014;24(2):161–9. - PubMed
  66. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Reprint—preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Phys Ther. 2009;89(9):873–80. - PubMed
  67. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5. - PubMed
  68. StataCorp LLCataCorp L. Stata Statistical Software: Release 12. StataCorp; 2011. - PubMed
  69. Boman E, Gustafson Y, Häggblom A, Santamäki Fischer R, Nygren B. Inner strength–associated with reduced prevalence of depression among older women. Aging Ment Health. 2015;19(12):1078–83. - PubMed
  70. Güzel A, Kara F. Determining the prevalence of depression among older adults living in Burdur, Turkey, and their associated factors. Psychogeriatrics. 2020;20(4):370–6. - PubMed
  71. Swarnalatha N. The prevalence of depression among the rural elderly in Chittoor District, Andhra Pradesh. J Clin Diagn Res. 2013;7(7):1356. - PubMed
  72. Ashe S, Routray D. Prevalence, associated risk factors of depression and mental health needs among the geriatric population of an urban slum, Cuttack, Odisha. Int J Geriatr Psychiatry. 2019;34(12):1799–807. - PubMed
  73. Girma M, Hailu M, Wakwoya A, Yohannis Z, Ebrahim J. Geriatric depression in Ethiopia: prevalence and associated factors. J Psychiatry. 2016;20(400): 1000400 - PubMed
  74. Mirkena Y, Reta MM, Haile K, Nassir Z, Sisay MM. Prevalence of depression and associated factors among older adults at ambo town, Oromia region, Ethiopia. BMC Psychiatry. 2018;18(1):1–7. - PubMed
  75. He G, Xie J, Zhou J, Zhong Z, Qin C, Ding S. Depression in left‐behind elderly in rural China: prevalence and associated factors. Geriatr Gerontol Int. 2016;16(5):638–43. - PubMed
  76. Cong L, Dou P, Chen D, Cai L. Depression and associated factors in the elderly cadres in Fuzhou, China: a community-based study. Int J Gerontol. 2015;9(1):29–33. - PubMed
  77. Feng L, Li P, Lu C, Tang W, Mahapatra T, Wang Y, et al. Burden and correlates of geriatric depression in the Uyghur elderly population, observation from Xinjiang, China. PLoS ONE. 2014;9(12):e114139. - PubMed
  78. Rajkumar A, Thangadurai P, Senthilkumar P, Gayathri K, Prince M, Jacob K. Nature, prevalence and factors associated with depression among the elderly in a rural south Indian community. Int Psychogeriatr. 2009;21(2):372–8. - PubMed
  79. Simkhada R, Wasti SP, Gc VS, Lee AC. Prevalence of depressive symptoms and its associated factors in older adults: a cross-sectional study in Kathmandu, Nepal. Aging Ment Health. 2018;22(6):802–7. - PubMed
  80. Manandhar K, Risal A, Shrestha O, Manandhar N, Kunwar D, Koju R, et al. Prevalence of geriatric depression in the Kavre district, Nepal: Findings from a cross-sectional community survey. BMC Psychiatry. 2019;19(1):1–9. - PubMed
  81. Arslantas D, Ünsal A, Ozbabalık D. Prevalence of depression and associated risk factors among the elderly in Middle A natolia, turkey. Geriatr Gerontol Int. 2014;14(1):100–8. - PubMed
  82. Charoensakulchai S, Usawachoke S, Kongbangpor W, Thanavirun P, Mitsiriswat A, Pinijnai O, et al. Prevalence and associated factors influencing depression in older adults living in rural Thailand: a cross-sectional study. Geriatr Gerontol Int. 2019;19(12):1248–53. - PubMed
  83. Forlani C, Morri M, Ferrari B, Dalmonte E, Menchetti M, De Ronchi D, et al. Prevalence and gender differences in late-life depression: a population-based study. Am J Geriatr Psychiatry. 2014;22(4):370–80. - PubMed
  84. Wilson K, Mottram P, Sixsmith A. Depressive symptoms in the very old living alone: prevalence, incidence and risk factors. Int J Geriatr Psychiatry. 2007;22(4):361–6. - PubMed
  85. Steffens DC, Fisher GG, Langa KM, Potter GG, Plassman BL. Prevalence of depression among older Americans: the Aging, Demographics and Memory Study. Int Psychogeriatr. 2009;21(5):879. - PubMed
  86. Abdul Manaf MR, Mustafa M, Abdul Rahman MR, Yusof KH, Abd Aziz NA. Factors influencing the prevalence of mental health problems among Malay elderly residing in a rural community: a cross-sectional study. PLoS ONE. 2016;11(6):e0156937. - PubMed
  87. Almeida OP, Flicker L, Fenner S, Smith K, Hyde Z, Atkinson D, et al. The Kimberley assessment of depression of older Indigenous Australians: prevalence of depressive disorders, risk factors and validation of the KICA-dep scale. PLoS ONE. 2014;9(4):e94983. - PubMed
  88. Weyerer S, Eifflaender-Gorfer S, Köhler L, Jessen F, Maier W, Fuchs A, et al. Prevalence and risk factors for depression in non-demented primary care attenders aged 75 years and older. J Affect Disord. 2008;111(2–3):153–63. - PubMed
  89. Jadav P, Patel MV. Prevalence of depression and factors associated with it in geriatric population in the rural area of Vadodara, Gujarat. 2017. - PubMed
  90. Sinha SP, Shrivastava SR, Ramasamy J. Depression in an older adult rural population in India. MEDICC Rev. 2013;15:41–4. - PubMed
  91. Kaji T, Mishima K, Kitamura S, Enomoto M, Nagase Y, Li L, et al. Relationship between late-life depression and life stressors: large-scale cross-sectional study of a representative sample of the Japanese general population. Psychiatry Clin Neurosci. 2010;64(4):426–34. - PubMed
  92. Fernández-Niño JA, Manrique-Espinoza BS, Bojorquez-Chapela I, Salinas-Rodríguez A. Income inequality, socioeconomic deprivation and depressive symptoms among older adults in Mexico. PLoS ONE. 2014;9(9):e108127. - PubMed
  93. Al-Shammari SA, Al-Subaie A. Prevalence and correlates of depression among Saudi elderly. Int J Geriatr Psychiatry. 1999;14(9):739–47. - PubMed
  94. Subramaniam M, Abdin E, Sambasivam R, Vaingankar JA, Picco L, Pang S, et al. Prevalence of depression among older adults-results from well-being of the Singapore elderly study. Ann Acad Med Singapore. 2016;45(4):123–33. - PubMed
  95. Assil S, Zeidan Z. Prevalence of depression and associated factors among elderly Sudanese: a household survey in Khartoum State. EMHJ-Eastern Mediterr Health J. 2013;19(5):435–40. - PubMed
  96. Haseen F, Prasartkul P. Predictors of depression among older people living in rural areas of Thailand. Bangladesh Med Res Counc Bull. 2011;37(2):51–6. - PubMed
  97. Ghubash R, El-Rufaie O, Zoubeidi T, Al-Shboul QM, Sabri SM. Profile of mental disorders among the elderly United Arab Emirates population: sociodemographic correlates. Int J Geriatr Psychiatry. 2004;19(4):344–51. - PubMed
  98. Abdo NM, Eassa S, Abdalla AM. Prevalence of depression among elderly and evaluation of interventional counseling session in Zagazig district-Egypt. J Am Sci. 2011;7(6). - PubMed
  99. Snowdon J, Lane F. The Botany survey: a longitudinal study of depression and cognitive impairment in an elderly population. Int J Geriatr Psychiatry. 1995;10(5):349–58. - PubMed
  100. McCall NT, Parks P, Smith K, Pope G, Griggs M. The prevalence of major depression or dysthymia among aged Medicare Fee-for-Service beneficiaries. Int J Geriatr Psychiatry. 2002;17(6):557–65. - PubMed
  101. Li N, Chen G, Zeng P, Pang J, Gong H, Han Y, et al. Prevalence of depression and its associated factors among Chinese elderly people: A comparison study between community-based population and hospitalized population. Psychiatry Res. 2016;243:87–91. - PubMed
  102. Mendes-Chiloff CL, Ramos-Cerqueira ATA, Lima MCP, Torres AR. Depressive symptoms among elderly inpatients of a Brazilian university hospital: prevalence and associated factors. Int Psychogeriatr. 2008;20(5):1028. - PubMed
  103. Prashanth A, Rakesh MPK, Praveena V, Preethi A, Prithvi S, Priyadharshini R, et al. Prevalence of depression and factors influencing it among geriatric population attending the outpatient department of a tertiary care hospital. Adv Med Sci. 2015;2:1–5. - PubMed
  104. Helvik AS, Skancke RH, Selbæk G. Screening for depression in elderly medical inpatients from the rural area of Norway: prevalence and associated factors. Int J Geriatr Psychiatry. 2010;25(2):150–9. - PubMed
  105. Anantapong K, Pitanupong J, Werachattawan N, Aunjitsakul W. Depression and associated factors among elderly outpatients in Songklanagarind Hospital, Thailand: a cross-sectional study. Songklanagarind Med J. 2017;35(2):139–48. - PubMed
  106. Organization WH. The mental health of older adults, 12 December 2017. 2019 - PubMed
  107. Luppa M, Sikorski C, Luck T, Ehreke L, Konnopka A, Wiese B, et al. Age-and gender-specific prevalence of depression in latest-life–systematic review and meta-analysis. J Affect Disord. 2012;136(3):212–21. - PubMed
  108. Wang J, Wu X, Lai W, Long E, Zhang X, Li W, et al. Prevalence of depression and depressive symptoms among outpatients: a systematic review and meta-analysis. BMJ Open. 2017;7(8):e017173. - PubMed
  109. Barcelos-Ferreira R, Izbicki R, Steffens DC, Bottino CM. Depressive morbidity and gender in community-dwelling Brazilian elderly: systematic review and meta-analysis. Int Psychogeriatr. 2010;22(5):712. - PubMed
  110. Salari N, Mohammadi M, Vaisi-Raygani A, Abdi A, Shohaimi S, Khaledipaveh B, et al. The prevalence of severe depression in Iranian older adults: a meta-analysis and meta-regression. BMC Geriatr. 2020;20(1):39. - PubMed
  111. de Waal MW, van der Weele GM, van der Mast RC, Assendelft WJ, Gussekloo J. The influence of the administration method on scores of the 15-item Geriatric Depression Scale in old age. Psychiatry Res. 2012;197(3):280–4. - PubMed
  112. Zhang H-H, Jiang Y-Y, Rao W-W, Zhang Q-E, Qin M-Z, Ng CH, et al. Prevalence of depression among empty-nest elderly in China: a meta-analysis of observational studies. Front Psych. 2020;11:608. - PubMed
  113. Pilania M, Yadav V, Bairwa M, Behera P, Gupta SD, Khurana H, et al. Prevalence of depression among the elderly (60 years and above) population in India, 1997–2016: a systematic review and meta-analysis. BMC Public Health. 2019;19(1):1–18. - PubMed
  114. Pilania M, Bairwa M, Kumar N, Khanna P, Kurana H. Elderly depression in India: An emerging public health challenge. Australas Med J. 2013;6(3):107. - PubMed
  115. Organization WH. World Health Day 2012: aging and health: a toolkit for event organizers. World Health Organization, 2012. - PubMed
  116. Mao G, Lu F, Fan X, Wu D. China's aging population: The present situation and prospects. Population change and impacts in Asia and the Pacific: Springer; 2020. p. 269–87. - PubMed
  117. Patel V, Abas M, Broadhead J, Todd C, Reeler A. Depression in developing countries: lessons from Zimbabwe. BMJ. 2001;322(7284):482–4. - PubMed

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