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Talbot HK, Martin ET, Gaglani M, et al. Coronavirus disease 2019 (COVID-19) Versus Influenza in Hospitalized Adult Patients in the United States: Differences in Demographic and Severity Indicators. Clin Infect Dis. 2021;73(12):2240-2247doi: 10.1093/cid/ciab123.
Talbot, H. K., Martin, E. T., Gaglani, M., Middleton, D. B., Ghamande, S., Silveira, F. P., Murthy, K., Zimmerman, R. K., Trabue, C. H., Olson, S. M., Petrie, J. G., Ferdinands, J. M., Patel, M. M., Monto, A. S. (2021). Coronavirus disease 2019 (COVID-19) Versus Influenza in Hospitalized Adult Patients in the United States: Differences in Demographic and Severity Indicators. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73(12), 2240-2247. https://doi.org/10.1093/cid/ciab123
Talbot, H Keipp, et al. "Coronavirus disease 2019 (COVID-19) Versus Influenza in Hospitalized Adult Patients in the United States: Differences in Demographic and Severity Indicators." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America vol. 73,12 (2021): 2240-2247. doi: https://doi.org/10.1093/cid/ciab123
Talbot HK, Martin ET, Gaglani M, Middleton DB, Ghamande S, Silveira FP, Murthy K, Zimmerman RK, Trabue CH, Olson SM, Petrie JG, Ferdinands JM, Patel MM, Monto AS. Coronavirus disease 2019 (COVID-19) Versus Influenza in Hospitalized Adult Patients in the United States: Differences in Demographic and Severity Indicators. Clin Infect Dis. 2021 Dec 16;73(12):2240-2247. doi: 10.1093/cid/ciab123. PMID: 34050659; PMCID: PMC8195096.
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Clin Infect Dis. 2021 Dec 16;73(12):2240-2247. doi: 10.1093/cid/ciab123.

Coronavirus disease 2019 (COVID-19) Versus Influenza in Hospitalized Adult Patients in the United States: Differences in Demographic and Severity Indicators.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

H Keipp Talbot, Emily T Martin, Manjusha Gaglani, Donald B Middleton, Shekhar Ghamande, Fernanda P Silveira, Kempapura Murthy, Richard K Zimmerman, Christopher H Trabue, Samantha M Olson, Joshua G Petrie, Jill M Ferdinands, Manish M Patel, Arnold S Monto,

Affiliations

  1. Department of Medicine and Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  2. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  3. Baylor Scott & White Health, Texas A&M University College of Medicine, Temple, Texas, USA.
  4. Department of Medical Education at Texas A&M University COM, Texas, USA.
  5. Department of Medicine, Division of Infectious Diseases, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  6. Department of Medicine, University of Tennessee Health Science Center, Saint Thomas Health, Nashville, Tennessee, USA.
  7. Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.

PMID: 34050659 PMCID: PMC8195096 DOI: 10.1093/cid/ciab123

Abstract

BACKGROUND: Novel coronavirus disease 2019 (COVID-19) is frequently compared with influenza. The Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) conducts studies on the etiology and characteristics of U.S. hospitalized adults with influenza. It began enrolling patients with COVID-19 hospitalizations in March 2020. Patients with influenza were compared with those with COVID-19 in the first months of the U.S. epidemic.

METHODS: Adults aged ≥ 18 years admitted to hospitals in 4 sites with acute respiratory illness were tested by real-time reverse transcription polymerase chain reaction for influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19. Demographic and illness characteristics were collected for influenza illnesses during 3 seasons 2016-2019. Similar data were collected on COVID-19 cases admitted before June 19, 2020.

RESULTS: Age groups hospitalized with COVID-19 (n = 914) were similar to those admitted with influenza (n = 1937); 80% of patients with influenza and 75% of patients with COVID-19 were aged ≥50 years. Deaths from COVID-19 that occurred in younger patients were less often related to underlying conditions. White non-Hispanic persons were overrepresented in influenza (64%) compared with COVID-19 hospitalizations (37%). Greater severity and complications occurred with COVID-19 including more ICU admissions (AOR = 15.3 [95% CI: 11.6, 20.3]), ventilator use (AOR = 15.6 [95% CI: 10.7, 22.8]), 7 additional days of hospital stay in those discharged alive, and death during hospitalization (AOR = 19.8 [95% CI: 12.0, 32.7]).

CONCLUSIONS: While COVID-19 can cause a respiratory illness like influenza, it is associated with significantly greater severity of illness, longer hospital stays, and higher in-hospital deaths.

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Keywords: COVID-19; ICU admissions; hospitalization; influenza; race/ethnicity

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