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Rezvani M, Letizia Manca M, Muntoni A, et al. From process effluents to intestinal health promotion: developing biopolymer-whey liposomes loaded with gingerol to heal intestinal wounds and neutralize oxidative stress. Int J Pharm. 2021;121389doi: 10.1016/j.ijpharm.2021.121389.
Rezvani, M., Letizia Manca, M., Muntoni, A., De Gioannis, G., Luis Pedraz, J., Gutierrez, G., Matos, M., Maria Fadda, A., & Manconi, M. (2021). From process effluents to intestinal health promotion: developing biopolymer-whey liposomes loaded with gingerol to heal intestinal wounds and neutralize oxidative stress. International journal of pharmaceutics, 121389. https://doi.org/10.1016/j.ijpharm.2021.121389
Rezvani, Maryam, et al. "From process effluents to intestinal health promotion: developing biopolymer-whey liposomes loaded with gingerol to heal intestinal wounds and neutralize oxidative stress." International journal of pharmaceutics vol. (2021): 121389. doi: https://doi.org/10.1016/j.ijpharm.2021.121389
Rezvani M, Letizia Manca M, Muntoni A, De Gioannis G, Luis Pedraz J, Gutierrez G, Matos M, Maria Fadda A, Manconi M. From process effluents to intestinal health promotion: developing biopolymer-whey liposomes loaded with gingerol to heal intestinal wounds and neutralize oxidative stress. Int J Pharm. 2021 Dec 16;121389. doi: 10.1016/j.ijpharm.2021.121389. Epub 2021 Dec 16. PMID: 34923053.
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Int J Pharm. 2021 Dec 16;121389. doi: 10.1016/j.ijpharm.2021.121389. Epub 2021 Dec 16.

From process effluents to intestinal health promotion: developing biopolymer-whey liposomes loaded with gingerol to heal intestinal wounds and neutralize oxidative stress.

International journal of pharmaceutics

Maryam Rezvani, Maria Letizia Manca, Aldo Muntoni, Giorgia De Gioannis, Jose Luis Pedraz, Gemma Gutierrez, Maria Matos, Anna Maria Fadda, Maria Manconi

Affiliations

  1. Department of Life and Environmental Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. Electronic address: [email protected].
  2. Department of Life and Environmental Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
  3. Department of Civil and Environmental Engineering and Architecture, University of Cagliari, Piazza d'Armi, 09123, Cagliari, Italy.
  4. NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain; Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain.
  5. Department of Chemical and Environmental Engineering, University of Oviedo, 33003 Oviedo, Spain.

PMID: 34923053 DOI: 10.1016/j.ijpharm.2021.121389

Abstract

As a sustainable strategy to valorize the main effluent of the cheese industry and potent environmental pollutant, whey, several biopolymer-whey vesicles loaded with gingerol were tailored for counteracting intestinal oxidative stress and boosting wound healing. An eco-friendly method was used to combine whey with four different water-dispersible biopolymers (xanthan gum, tragacanth, Arabic gum and sodium alginate), phospholipid and a natural antioxidant (gingerol). The results of cryogenic transmission microscopy and dynamic light scattering indicated that the vesicles were mostly unilamellar and small in size (∼100 nm) with low polydispersity index, high negative zeta potential and ability to entrap a high amount of gingerol (up to 94%). The vesicles could maintain their structures in acidic and neutral media and Turbiscan® technology confirmed their stability during the storage. Vesicles prepared with whey and tragacanth exhibited the highest capability to protect intestinal cells from damages induced by hydrogen peroxide. When Arabic and tragacanth gums were added to the whey vesicles, the closure rate of the scratched area was fast and no trace of the wound was observed after 72 h of treatment. These promising findings could open a new horizon in the application of whey in nanomedicine for the treatment of intestinal damages.

Copyright © 2021. Published by Elsevier B.V.

Keywords: Biopolymer; Gingerol; Intestinal wound healing; Oxidative stress; Whey

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

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